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Table 1 Serum metabolites that differed among the dietary treatment groups1

From: Trace amounts of antibiotic altered metabolomic and microbial profiles of weaned pigs infected with a pathogenic E. coli

Metabolite

Fold change1

VIP2

FDR3

TRA4 vs. REC5, d 0 before ETEC challenge

 Fructose

2.13

1.88

0.108

 Mannonic acid

2.21

2.01

0.083

 Propyleneglycol

2.38

1.76

0.122

CON6 vs. REC, d 5 post-inoculation

 Mannitol

0.23

1.48

0.115

 Inosine

0.41

1.63

0.076

 Glycerol

2.09

1.79

0.045

 Galactonic acid

2.26

1.65

0.076

 Propyleneglycol

2.51

1.47

0.119

 Shikimic acid

2.64

1.86

0.036

TRA vs. REC, d 5 post-inoculation

 2-hydroxyvaleric acid

0.24

2.13

0.001

 P-hydroxylphenyllactic acid

0.30

1.10

0.145

 Pipecolinic acid

0.38

1.58

0.024

 1-methylhydantoin

0.40

1.51

0.031

 Histidine

0.45

1.98

0.002

 Creatine

0.46

1.51

0.031

 Myo-inositol

2.01

1.93

0.002

 Guanine

2.03

1.83

0.005

 Oleic acid

2.03

1.18

0.114

 Montanic acid

2.05

1.57

0.024

 Galactonic acid

2.11

1.42

0.046

 Hypoxanthine

2.14

1.80

0.006

 Glycerol

3.26

1.35

0.067

 Propyleneglycol

4.04

2.00

0.002

 Shikimic acid

4.47

1.63

0.020

 Taurine

5.58

1.27

0.082

CON vs. REC, d 11 post-inoculation

 Glycerol

0.33

1.74

0.181

 Inositol-4-monophosphate

0.48

1.92

0.165

 Chenodeoxycholic acid

3.01

1.84

0.171

TRA vs. REC, d 11 post-inoculation

 P-tolyl glucuronide

0.26

2.10

0.106

 Dlycerol

0.30

1.84

0.195

 Mannitol

0.30

1.90

0.158

 2-ketoisocaproic acid

0.45

1.90

0.158

 Inositol-4-monophosphate

0.48

2.08

0.106

 Chenodeoxycholic acid

4.67

2.04

0.109

  1. 1Fold change values less than one indicate that the differential metabolites were reduced in the CON compared to REC or TRA compared to REC, respectively
  2. 2VIP Variable Importance in the projection
  3. 3FDR False discovery rate
  4. 4TRA Trace amounts of antibiotic
  5. 5REC Label-recommended dose of antibiotic
  6. 6CON Control