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Table 1 Serum metabolites that differed among the dietary treatment groups1

From: Trace amounts of antibiotic altered metabolomic and microbial profiles of weaned pigs infected with a pathogenic E. coli

Metabolite Fold change1 VIP2 FDR3
TRA4 vs. REC5, d 0 before ETEC challenge
 Fructose 2.13 1.88 0.108
 Mannonic acid 2.21 2.01 0.083
 Propyleneglycol 2.38 1.76 0.122
CON6 vs. REC, d 5 post-inoculation
 Mannitol 0.23 1.48 0.115
 Inosine 0.41 1.63 0.076
 Glycerol 2.09 1.79 0.045
 Galactonic acid 2.26 1.65 0.076
 Propyleneglycol 2.51 1.47 0.119
 Shikimic acid 2.64 1.86 0.036
TRA vs. REC, d 5 post-inoculation
 2-hydroxyvaleric acid 0.24 2.13 0.001
 P-hydroxylphenyllactic acid 0.30 1.10 0.145
 Pipecolinic acid 0.38 1.58 0.024
 1-methylhydantoin 0.40 1.51 0.031
 Histidine 0.45 1.98 0.002
 Creatine 0.46 1.51 0.031
 Myo-inositol 2.01 1.93 0.002
 Guanine 2.03 1.83 0.005
 Oleic acid 2.03 1.18 0.114
 Montanic acid 2.05 1.57 0.024
 Galactonic acid 2.11 1.42 0.046
 Hypoxanthine 2.14 1.80 0.006
 Glycerol 3.26 1.35 0.067
 Propyleneglycol 4.04 2.00 0.002
 Shikimic acid 4.47 1.63 0.020
 Taurine 5.58 1.27 0.082
CON vs. REC, d 11 post-inoculation
 Glycerol 0.33 1.74 0.181
 Inositol-4-monophosphate 0.48 1.92 0.165
 Chenodeoxycholic acid 3.01 1.84 0.171
TRA vs. REC, d 11 post-inoculation
 P-tolyl glucuronide 0.26 2.10 0.106
 Dlycerol 0.30 1.84 0.195
 Mannitol 0.30 1.90 0.158
 2-ketoisocaproic acid 0.45 1.90 0.158
 Inositol-4-monophosphate 0.48 2.08 0.106
 Chenodeoxycholic acid 4.67 2.04 0.109
  1. 1Fold change values less than one indicate that the differential metabolites were reduced in the CON compared to REC or TRA compared to REC, respectively
  2. 2VIP Variable Importance in the projection
  3. 3FDR False discovery rate
  4. 4TRA Trace amounts of antibiotic
  5. 5REC Label-recommended dose of antibiotic
  6. 6CON Control