Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows

Table 5 Effects of MBA on ERα and ERβ in serum and organs of first-parity gilts when exposed to ZEA^c

Items, pg/mg		Dietary treatment^d				PEM^e	P-value
Items, pg/mg		CO	COA	MO	MOA	PEM^e	Main effect of ZEA	Main effect of MBA	ZEA × MBA
Serum (60 d)	ERα	1192^a	1135^a	1455^b	1324^c	64.41	< 0.01	0.38	< 0.01
Serum (60 d)	ERβ	2247^a	2240^b	3085^b	2585^c	100.89	< 0.01	0. 49	< 0.01
Serum (114 d)	ERα	1535^b	1543^b	1749^a	1649^ab	69.35	< 0.01	0.22	< 0.01
Serum (114 d)	ERβ	1723^b	1724^b	2220^a	1815^b	99.75	< 0.01	< 0.01	< 0.01
Liver	ERα	4.42	4.61	4.91	4.47	0.45	0.52	0.69	0.33
Liver	ERβ	4.31	4.28	5.19	4.12	0.79	0.54	0.35	0.24
Spleen	ERα	4.21	4.37	5.35	4.87	0.61	0.16	0.61	0.10
Spleen	ERβ	3.91^ab	4.37^ab	5.11^a	3.30^b	0.78	0.15	0.24	< 0.01
Kidney	ERα	4.55	4.67	5.21	4.97	058	0.47	0.88	0.31
Kidney	ERβ	4.32	4.32	5.47	4.55	0.77	0.38	0.48	0.22
Uterus	ERα	14.39	14.80	15.26	14.98	0.60	0.35	0.81	0.21
Uterus	ERβ	17.98^b	19.44^ab	21.63^a	19.45^ab	1.35	0.05	0.72	< 0.01
Ovary	ERα	11.89	12.10	12.87	12.05	0.69	0.38	0.56	0.22
Ovary	ERβ	13.82^b	13.84^b	17.43^a	13.55^b	1.36	0.05	0.09	< 0.01
Mammary gland	ERα	7.99	8.14	8.59	8.25	0.45	0.42	0.77	0.24
Mammary gland	ERβ	7.70^b	8.51^ab	10.43^a	8.19^ab	1.13	0.06	0.30	< 0.01

^a,b Mean values within a row without a common superscript differ significantly (P < 0.05)
^c Means for serum represent eight replications per treatment (n = 8/group) and means for organs represent six replications per treatment (n = 6/group)
^d CO, a positive basal control diet contained 60.52% normal corn; COA, CO + 2 g MBA/kg diet; 3) MO, a negative basal control diet contained 60.52% moldy corn; MOA, MO + 2 g MBA/kg diet; ZEA Zearalenone, MBA Mycotoxin biodegradation agent, ERα Estrogen receptor-α, ERβ Estrogen receptor-β, MBA Mycotoxin biodegradation agent
^e Pooled standard error of the means

ISSN: 2049-1891