Chronic corticosterone disrupts the circadian rhythm of CRH expression and m6A RNA methylation in the chicken hypothalamus

Table 5 Circadian rhythm parameters of all clock genes in pituitary, as determined by cosinor analyses

Index	Group	CLOCK	BMAL1	CRY1	CRY2	PER2	PER3
Mesor	CON	1.15 ± 0.09	1.33 ± 0.06	0.86 ± 0.03	0.86 ± 0.05	0.59 ± 0.02	0.64 ± 0.06
Mesor	CORT	0.88 ± 0.05*	1.36 ± 0.08	0.66 ± 0.05*	ND	0.49 ± 0.04	0.65 ± 0.07
Amplitude	CON	0.24 ± 0.13	0.50 ± 0.09	0.21 ± 0.05	0.21 ± 0.06	0.41 ± 0.02	0.52 ± 0.09
Amplitude	CORT	0.11 ± 0.08	0.66 ± 0.12	0.28 ± 0.07	ND	0.30 ± 0.05	0.51 ± 0.11
Acrophase, h	CON	18.25 ± 2.00	10.34 ± 0.69	5.04 ± 0.84	4.81 ± 1.15	2.87 ± 0.25	22.53 ± 0.66
Acrophase, h	CORT	19.10 ± 2.60	10.57 ± 0.66	7.15 ± 0.84	ND	1.97 ± 0.68	21.92 ± 0.76

Values are means ± SEM. *P < 0.05, compared with CON group. ND represents not determined as there was no circadian rhythm

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