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Fig. 6 | Journal of Animal Science and Biotechnology

Fig. 6

From: Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Fig. 6

Endoplasmic reticulum stress-associated apoptosis in C2C12 cells was induced by RyR1-knockout (n = 3). (A-B) Apoptosis detection of RyR1-null cells through flow cytometry. (C-D) The protein expression of Cyclin D1, caspase-3 (CASP3), and cleaved-CASP3 in RyR1-KO cells. (E-H) The expression of proteins related to ER stress or ER stress-induced apoptosis in RyR1-KO cells. RyR1−/− and RyR1+/− represent homozygote and heterozygote of RyR1-knockout, respectively. The data are presented as the mean ± SEM. *Represents significant difference between the two groups (P < 0.05)

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891