Fig. 4
From: MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro
Mechanisms of ZEA toxicity regulated by miRNAs. After ZEA is exposed to the cell membrane, it activates PKC through the membrane surface protein GRP30, and induces cytotoxicity by activating the P38 signaling pathway. Overexpressed miR-7 can recognize the synthesis and secretion of FSH through targeted regulation of FOS gene expression, which seriously affects the normal estrogen secretion of female animals and induces ZEA toxicity. ZEA triggers apoptosis and cytotoxicity by activating the apoptotic executioner caspase3, which is specifically manifested as the overexpression of intracellular miR-1343, miR-331-3p, and miR-744, the expression level of PaK4 and ElK1 decreases, and the expression of Bad rise