Fig. 3
From: MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro
Mechanisms of DON toxicity regulated by miRNAs. The low expression of miR-450b-3p in HCC cells inhibits the expression of its target gene PGK1, and then promotes the proliferation of cancer cells by inhibiting the phosphorylation of Akt. After exposure to DON, the combination of lncRNA GM20319 and miR-7240-5p significantly inhibits the expression of GNE gene, which in turn stimulates the decrease of sialic acid activity, the decrease of SOD1 expression, and the upregulation of IL-1β expression, and finally triggers liver injury