Fig. 2
From: MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro
Mechanisms of AFB1 toxicity regulated by miRNAs. After exposure to AFB1, miR-34a and miR-33a-5p inhibit the expression of β-catenin in the Wnt signaling pathway, which in turn causes the decrease of c-myc and cyclin D1, and results in the arrest of cell cycle S phase and the risk of HCC. Overexpression of miR-138-1 can significantly inhibit the activation of PDK1, thereby inhibiting the expression of related proteins in the PI3K/Akt signaling pathway, and ultimately alleviating the malignant transformation of cells caused by AFB1