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Fig. 1 | Journal of Animal Science and Biotechnology

Fig. 1

From: MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro

Fig. 1

Mechanisms of OTA toxicity regulated by miRNAs. After OTA exposure, by activating miR-21 and miR-200a in cells, it significantly phosphorylates ERK1/2 and induces the activation and expression of COX-2, which in turn induces the occurrence of inflammation and EMT in the body and leads to cytotoxicity. OTA can indirectly inhibit HO-1 expression of inhibition of Nrf2 signaling by miR-132 or activation of miR-200c, thereby increasing ROS levels in vivo and increasing nephrotoxicity. OTA can activate collagen expression of miR-29b and cause renal fibrosis. OTA can inhibit the prolactin receptor (PRLRA) by miR-731 and induce cerebral hemorrhage. OTA activates Bcl-W via miR-122, which in turn stimulates caspase-3 and triggers apoptosis

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