Lovastatin as a supplement to mitigate rumen methanogenesis: an overview

Table 3 Effects of lovastatin on rumen fermentation variables

pH	NH₃-N	Total VFA	Acetate	Propionate	Butyrate	A:P^a	Digestibility	Reference
*In vitro* experiments
≈	≈	≈	≈	≈	≈	≈	≈	[39]
≈	↓	≈	↑	↓	≈	NR^b	≈	[40]
↑	NR	≈	≈	↓	≈	≈	↑	[34]
≈	NR	≈	≈	≈	≈	NR	≈	[41]
NR	NR	≈	↓	≈	≈	≈	≈	[36]
≈	↑	≈	↓	↑	≈	NR	↑	[42]
≈	NR	↓	↓	↑	≈	↓	NR	[31]
≈	≈	↓	↓	↑	↓	↓	≈	[43]
*In vivo* experiments
≈	≈	≈	≈	≈	≈	≈	≈	[48]
NR	NR	↓	≈	≈	≈	≈	NR	[49]
NR	NR	↓	↓	≈	≈	↓	NR	[36]
NR	≈	≈	≈	≈	≈	↓	≈	[50]
NR	NR	≈	≈	↑	↑	↑	↑	[35]
≈	NR	≈	≈	↑	≈	↓	≈	[37]

ISSN: 2049-1891