L. reuteri ZJ617 inhibits inflammatory and autophagy signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide

Table 4 Altered metabolic pathways identified based on significant changes in concentrations of metabolites in the piglet intestine in 2 group comparisons

Group comparison	Altered metabolic pathway
CON vs LPS	Alanine, aspartate, and glutamate metabolism Glyoxylate and dicarboxylate metabolism
CON vs ZJ617 + LPS	Valine, leucine and isoleucine biosynthesis Aminoacyl-tRNA biosynthesis Glycine, serine and threonine metabolism Biosynthesis of unsaturated fatty acids Arginine biosynthesis
LPS vs ZJ617 + LPS	Aminoacyl-tRNA biosynthesis Valine, leucine and isoleucine biosynthesis Alanine, aspartate and glutamate metabolism Phenylalanine metabolism Glycine, serine and threonine metabolism Arginine biosynthesis

CON control piglets orally inoculated with PBS; LPS piglets i.p. injected with LPS (25 μg/kg body weight); ZJ617 + LPS, piglets orally inoculated with ZJ617 (1 × 10¹⁰ CFU/d) for 2 weeks before intraperitoneal injection (i.p.) of LPS. ZJ617, Lactobacillus reuteri ZJ617

ISSN: 2049-1891