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Table 2 List of significantly altered metabolites in the intestine of piglets between CON and ZJ617 + LPS groups

From: L. reuteri ZJ617 inhibits inflammatory and autophagy signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide

Metabolite

Similarity

R.T.

Mass

VIP

P value

FC

Glutamine 4TMS minor

854.9641

11.57

129

2.25

0.0007

0.09

Phenylacetic acid

939.3611

23.96

204

2.14

0.0007

0.23

Alanine

839.9175

11.35

115

2.07

0.0049

2.60

Glycine

730.6577

5.77

147

2.06

0.0025

1.75

Agmatine

741.8409

20.1

131

1.95

0.0044

1.38

2-Monopalmitin

649.5071

22.29

361

1.80

0.0408

0.21

2-Deoxytetronic acid NIST

870.2739

15.66

147

1.78

0.0120

0.21

Erythronic acid

616.9285

16.51

174

1.71

0.0360

0.31

Capric acid

901.6143

22

204

1.70

0.0567

0.04

z-C08 FAME internal standard

611.1466

4.48

207

1.63

0.0426

1.34

z-Hexose perTMS

985.0225

4.82

147

1.60

0.0522

0.82

Methionine sulfoxide minor

602.5514

5.26

151

1.58

0.0384

1.30

Allantoic acid (dehydrated) 3TMS minor

650.7138

21

91

1.57

0.0279

3.07

  1. CON control piglets orally inoculated with PBS; ZJ617 + LPS, piglets orally inoculated with ZJ617 (1 × 1010 CFU/d) for 2 weeks before i.p. injection of lipopolysaccharides (25 μg/kg body weight). Metabolites with VIP > 1.5 are shown in the Table. FC, fold-change of the peak intensity for the CON group against the LPS + ZJ617 group (n = 6); P values were calculated according to Student’s t test
  2. ZJ617, Lactobacillus reuteri ZJ617; RT, retention time; VIP, variable importance in projection