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Fig. 8 | Journal of Animal Science and Biotechnology

Fig. 8

From: TLR7/8 signalling affects X-sperm motility via the GSK3 α/β-hexokinase pathway for the efficient production of sexed dairy goat embryos

Fig. 8

TLR7/8 signalling mechanisms affect ATP production in X-sperm and Y-sperm of goat, respectively. In Y-sperm, mitochondrial and glycolytic ATP production occur regardless of the presence of R848. Thus, Y-sperm showed normal high-speed motility. In X-sperm, the activation of TLR7/8 localised in the sperm tail via phosphorylated NFκB and GSK3α/β, and via a PI3K/AKT-independent mechanism. Then suppressed the activity of hexokinase. As a result, ATP production in X-sperm was decreased under R848 condition. Thus, only X-sperm showed low-speed motility under R848 condition

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891