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Table 7 Effect of resveratrol supplementation on the apoptosis of intestinal epithelial cells in DON-challenged pigletsa

From: Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol

Variable

Treatments

SEM

P-value

CON

DON

RES

DON+RES

DON

RES

RES × DON

TUNEL-positive cell percentage

 TUNEL, %

7.44c

23.30a

6.80c

16.16b

1.60

< 0.001

0.027

0.050

Protein expressions involved in apoptosis

 BCL-2/β-actin

0.28a

0.10c

0.29a

0.19b

0.03

< 0.001

0.095

0.094

 BAX/β-actin

0.37c

1.12a

0.41c

0.91b

0.07

< 0.001

0.230

0.081

 Caspase3/β-actin

0.25c

2.09a

0.23c

0.93b

0.11

< 0.001

< 0.001

< 0.001

  1. aValues are means and standard error of the means, n = 8 per treatment; labeled means in a row without a common letter differ, P ≤ 0.05; Bax, Bcl-2 associated x protein; BCL-2 B-cell lymphoma/ leukemia 2, CON Control, DON Deoxynivalenol, DON+RES Combination of deoxynivalenol and resveratrol, RES Resveratrol, SEM Standard error of the mean, TUNEL Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling