Pyrroloquinoline quinone regulates the redox status in vitro and in vivo of weaned pigs via the Nrf2/HO-1 pathway

Table 3 Effects of dietary PQQ supplementation on antioxidant activities in weaned pigs¹

Items	Pyrroloquinoline quinone disodium levels,%				SEM	P-value
Items	0	0.15	0.30	0.45	SEM	ANOVA	Linear	Quadratic
Serum
SOD, U/mg	46.42^b	47.04^b	52.95^a	50.24^ab	1.37	0.01	0.09	0.23
GSH-Px, U/mg	727.62^b	688.16^b	812.73^a	908.16^a	35.90	0.02	0.06	0.19
MDA, nmol/mg	3.09^a	2.52^ab	2.30^b	2.25^b	0.20	< 0.01	< 0.01	0.07
CAT, IU/mg	3.14	4.00	4.57	3.62	0.48	0.21	0.36	0.07
Liver
SOD, U/mg	156.16^b	161.53^b	183.95^ab	222.86^a	11.10	< 0.01	< 0.01	0.15
GSH-Px, U/mg	968.42^b	974.70^b	1041.32^a	1029.44^ab	17.14	< 0.01	0.12	0.49
MDA, nmol/mg	3.38^a	3.12^a	1.45^b	1.64^b	0.32	0.01	0.05	0.60
CAT, U/mg	38.12	39.88	40.71	45.39	4.71	0.73	0.30	0.76
Heart
SOD, U/mg	163.34	171.12	184.78	193.39	8.40	0.09	0.01	0.96
GSH-Px, U/mg	500.78^b	548.85^a	544.61^a	537.97^a	19.24	< 0.01	0.09	0.06
MDA, nmol/mg	3.53	4.41	2.82	1.66	0.35	0.31	0.23	0.17
CAT, U/mg	4.16	3.92	4.35	4.31	1.04	0.99	0.85	0.92

¹ SEM standard error of the mean; the values are means ± SEM; 6 replicates. The linear and quadratic differences are with respect to pyrroloquinoline quinone disodium levels. Means within a row lacking a common letter are significantly different (P < 0.05). Antioxidant activities are expressed per mg of protein

ISSN: 2049-1891