Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota

Table 6 Effects of exogenously introduced SCFAs on the mRNA abundances for key factors associated with glucose metabolism in longissimus dorsi of GF pigs ^a

Items	GF	FA	P-value
FOXO-1	1.00 ± 0.44	1.35 ± 0.34	0.20
Sirt1	1.00 ± 0.02	0.86 ± 0.03	0.11
INSR	1.00 ± 0.09	0.99 ± 0.21	0.97
INS1	1.00 ± 0.15	1.08 ± 0.09	0.64
PIK3	1.00 ± 0.09	0.96 ± 0.07	0.73
GSK3	1.00 ± 0.04	1.01 ± 0.08	0.91

^a GF germ-free, FA short-chain fatty acids, FOX-1 foxo1 forkhead box O1, Sirt1 silent information regulator 1, INSR insulin receptor, IRS1 insulin receptor substrate 1, PIK3 phosphatidylinositol 3-kinase catalytic subunit type 3, GSK3 glycogen synthase kinase 3. Values are means ± SEMs, n = 6/group

ISSN: 2049-1891