Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota

Table 4 Effects of exogenously introduced SCFAs on the mRNA abundances for key factors associated with lipid metabolism in longissimus dorsi of GF pigs ^a

Items	GF	FA	P-value
ACC	1.00 ± 0.14	0.79 ± 0.03	0.19
FAS	1.00 ± 0.33	0.68 ± 0.06	0.37
CD36	1.00 ± 0.07	0.71 ± 0.06	0.02
LPL	1.00 ± 0.09	0.81 ± 0.04	0.08
SREBP-1C	1.00 ± 0.18	0.65 ± 0.06	0.11
PPKAA1	1.00 ± 0.08	0.91 ± 0.07	0.44
PPKAA2	1.00 ± 0.03	1.07 ± 0.06	0.39
CPT-1B	1.00 ± 0.15	1.14 ± 0.10	0.44
PGC-1α	1.00 ± 0.08	1.58 ± 0.39	0.19
PNPLA2	1.00 ± 0.16	0.97 ± 0.14	0.90

^a GF germ-free, FA short-chain fatty acids, ACC acetyl-CoA carboxylase, FAS fatty acid synthase, CD36 fatty acid transporter CD36, LPL lipoprotein lipase, SREBP-1C sterol regulatory element binding protein 1C, PRKAA1 AMP activated alpha 1, PRKAA2 AMP activated alpha 2, CPT-1B carnitine palmitoyltransferase 1 B, PGC-1α peroxisome proliferator-activated receptor gamma coactivator-1α, PNPLA2 patatin-like phospholipase domain-containing protein 2. Values are means ± SEMs, n = 6/group

ISSN: 2049-1891