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Table 3 Effects of exogenously introduced SCFAs on the mRNA abundances for key factors associated with lipid metabolism in colon and liver of GF pigs a

From: Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota

Items

GF

FA

P-value

Colon

 ANGPTL4

1.00 ± 0.13

1.48 ± 0.17

0.06

 PPAR-γ

1.00 ± 0.07

0.95 ± 0.14

0.75

Liver

 ACC

1.00 ± 0.17

0.63 ± 0.05

< 0.01

 FAS

1.00 ± 0.16

0.56 ± 0.03

0.03

 CD36

1.00 ± 0.25

0.60 ± 0.17

0.19

 LPL

1.00 ± 0.11

0.69 ± 0.13

0.11

 SREBP-1C

1.00 ± 0.09

0.72 ± 0.08

0.04

 PPKAA1

1.00 ± 0.10

1.10 ± 0.09

0.47

 PPKAA2

1.00 ± 0.13

0.99 ± 0.08

0.95

 CPT-1B

1.00 ± 0.14

0.98 ± 0.11

0.93

 PGC-1α

1.00 ± 0.16

2.02 ± 0.43

0.06

 PNPLA2

1.00 ± 0.11

0.86 ± 0.15

0.47

  1. a GF germ-free, FA short-chain fatty acids, ANGPTL4 angiopoietin-like 4, PPAR-γ peroxisome proliferator-activated receptor gamma, ACC acetyl-CoA carboxylase, FAS fatty acid synthase, CD36 fatty acid transporter CD36, LPL lipoprotein lipase, SREBP-1C sterol regulatory element binding protein 1C, PRKAA1 AMP activated alpha 1, PRKAA2 AMP activated alpha 2, CPT-1B carnitine palmitoyltransferase 1 B, PGC-1α peroxisome proliferator-activated receptor gamma coactivator-1α, PNPLA2 patatin-like phospholipase domain-containing protein 2. Values are means ± SEMs, n = 6/group