TY - JOUR AU - Choi, Hee Jung AU - Jin, So Dam AU - Rengaraj, Deivendran AU - Kim, Jin Hwa AU - Pain, Bertrand AU - Han, Jae Yong PY - 2021 DA - 2021/03/04 TI - Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells JO - Journal of Animal Science and Biotechnology SP - 40 VL - 12 IS - 1 AB - NANOG is a core transcription factor (TF) in embryonic stem cells (ESCs) and primordial germ cells (PGCs). Regulation of the NANOG gene by TFs, epigenetic factors, and autoregulatory factors is well characterized in ESCs, and transcriptional regulation of NANOG is well established in these cells. Although NANOG plays a key role in germ cells, the molecular mechanism underlying its transcriptional regulation in PGCs has not been studied. Therefore, we investigated the mechanism that regulates transcription of the chicken NANOG (cNANOG) gene in PGCs and ESCs. SN - 2049-1891 UR - https://doi.org/10.1186/s40104-021-00563-5 DO - 10.1186/s40104-021-00563-5 ID - Choi2021 ER -