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Table 3 Blood parameters in response to an intramammary inflammatory challenge with Streptococcus uberis in animal fed a control diet (CON), or a diet supplemented with a Saccharomyces cerevisiae fermentation product (NTK)

From: Feeding a Saccharomyces cerevisiae fermentation product improves udder health and immune response to a Streptococcus uberis mastitis challenge in mid-lactation dairy cows

Parameter2

TRT1

SEM

P-value

CON

NTK

TRT

Time

TRT×Time

Phase 2

Metabolism

  Glucose, mmol/L

4.68

4.74

0.12

0.70

<.0001

0.99

  NEFA, mmol/L

0.119

0.124

0.013

0.81

0.04

0.16

  BHB, mmol/L

0.513

0.519

0.031

0.87

<.0001

0.75

  Cholesterol, mmol/L

5.65

5.19

0.32

0.32

0.0004

0.92

  Urea, mmol/L

4.55

5.00

0.17

0.08

<.0001

0.40

  Creatinine, μmol/L

79.33

80.05

1.91

0.79

<.0001

0.05

Inflammation and acute phase proteins

  IL-1β, pg/mL

80.93

47.44

24.7

0.35

0.13

0.05

  IL-6, pg/mL

284.7

293.3

44.2

0.89

0.16

0.76

  MPO, U/L

433.8

427.4

18.5

0.81

<.0001

0.27

  Haptoglobin, g/L

0.555

0.546

0.101

0.94

<.0001

0.33

  Albumins, g/L

37.84

37.93

0.52

0.90

<.0001

0.85

  Bilirubin, total, μmol/L

2.38

2.12

0.13

0.17

0.06

0.11

  Ceruloplasmin, μmol/L

3.18

3.14

0.24

0.90

<.0001

0.79

Oxidative status

  ROMt, mg H2O2/100 mL

16.57

16.26

0.86

0.80

<.0001

0.68

  NOx, μmol/L

21.91

21.55

0.50

0.62

0.01

0.93

  NO2, μmol/L

5.33

5.31

0.29

0.96

0.04

0.74

  NO3, μmol/L

16.72

16.15

0.36

0.28

0.15

0.97

  FRAP, μmol/L

132.3

134.2

5.3

0.80

<.0001

0.35

  Paraoxonase, U/mL

91.1

90.09

4.74

0.88

0.001

0.95

Liver enzymes

  Alkaline phosphatase, U/L

56.80

63.89

4.53

0.28

<.0001

0.54

  AST, U/L

88.85

115.19

10.84

0.10

<.0001

0.40

  GGT, U/L

31.32

38.06

4.15

0.27

<.0001

0.89

Minerals

  Ca, mmol/L

2.43a

2.55b

0.03

0.01

0.009

0.28

  Cl, mmol/L

101.8

101.5

0.6

0.75

<.0001

0.34

  K, mmol/L

4.55

4.57

0.05

0.80

0.004

0.83

  Mg, mmol/L

1.06

1.01

0.02

0.09

<.0001

0.71

  Na, mmol/L

142.8

143.7

0.4

0.17

<.0001

0.05

  P, mmol/L

1.97

1.94

0.08

0.78

0.10

0.70

  Zn, μmol/L

9.84

11.20

1.06

0.37

<.0001

0.66

  1. 1TRT Treatment, CON Control, NTK NutriTek® supplemented group (19 g/d)
  2. 2NEFA Non-esterified fatty acids, BHB β-hydroxy butyrate, MPO Myeloperoxidase, IL1β and IL6 Interleukin 1 beta and 6, NOx Nitric oxides, FRAP Ferric reducing ability of plasma, ROMt Total reactive oxygen metabolites, GGT γ-glutamyl transferase, AST Aspartate aminotransferase