Stage | Dietary manipulationa | Effect on biomarker concentrationsb | Reference |
---|---|---|---|
Transition period | RP-Met or RP-Chol supply from −21 to 30 d relative to calving | ↓ IL-1β and haptoglobin with RP-Met ↑ IL-6 with RP-Met ↑ PON, albumin and cholesterol with RP-Met ↑ Liver GSH and GSR with RP-Met | [25] |
RP-Met supply from − 28 to 30 d relative to calving | ↓ Haptoglobin with RP-Met ↓ ROM with RP-Met ↑ IL-6 with RP-Met ↑ PON, albumin and cholesterol with RP-Met ↑ FRAP, β-carotene and tocopherol with RP-Met ↑ Liver GSH and GSR with RP-Met | [29] | |
RP-Met or RP-Chol supply from − 21 to 21 d relative to calving | ↑ IL-2 with RP-Met and RP-Chol ↓ IL-6 and TNF with RP-Met and RP-Chol ↑Total antioxidant capacity, GPX and vitamin E with RP-Met and RP-Chol ↓ Total bilirubin, ALP and MDA with RP-Met and RP-Chol ↑ TPP with RP-Chol ↓ GPT and GOT with RP-Chol ↓ BUN with RP-Met | [99] | |
Met supply (RP-Met or Met-analogue) from − 21 to 30 d relative to calving | ↓Ceruloplasmin and SAA with Met ↑ ORAC with Met | [33] | |
RP-Met or RP-Chol supply from − 21 to 30 d relative to calving | ↓ IL-1β after whole blood LPS challenge postpartum with RP-Met ↑ Neutrophil and monocyte phagocytosis and oxidative burst postpartum with RP-Met ↑ Monocyte phagocytosis with RP-Chol | [100] | |
RP-Chol at 25 g/d prepartum and 50 g/d postpartum of Chol ions from − 21 to 60 d relative to calving | ↓ Liver TLI and TAG with Chol ↓ Liver TAG:glycogen ratio with Chol ↑ Plasma TAG with Chol | [101] | |
Mid lactation | Chol ions at 0, 6.25, 12.5 or 25 g/d through abomasal infusion with restricted intake management during 4 d | ↓ Liver CBS activity linearly with Chol ↑ Liver taurine with Chol ↑ Plasma α-tocopherol and β-carotene with Chol ↓ Plasma AST and bilirubin with Chol ↑ PON with Chol | [37] |
Dry off | RP-Chol at 0, 6.5, 12.9, 19.4 or 25.8 g/d of Chol ions during 15 d with feed-restriction and fat-loading management | ↑ Liver lipotropic effects with up to 25.8 g/d of Chol ions in NNB cows ↑ Liver glycogen and TAG with 6.5 g/d of Chol ions in NNB cows | [102] |