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Table 1 Pearson correlation coefficients among hepatic cystathionine β-synthase (CBS), betaine homocysteine methyltransferase (BHMT) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) activity, liver triacylglycerol (TAG), dry matter intake (DMI), milk yield (MY), plasma methionine (Met), liver glutathione (GSH) and liver Met in periparal dairy cowsa

From: Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle

Variable CBS activity MTR activity BHMT activity Liver TAG DMI MY Plasma Met Total liver GSH Liver Met
MTR activity −0.17*         
BHMT activity 0.50* −0.002        
Liver TAG 0.31* 0.09 0.29*       
DMI 0.29* −0.28* −0.12+ 0.16*      
MY 0.66* −0.36* 0.13+ 0.05 0.78*     
Plasma Met 0.12+ −0.31* −0.07 −0.09 0.26* 0.24*    
Total liver GSH −0.06 0.10 0.05 −0.06 −0.06 − 0.06 −0.21*   
Liver Met 0.83* −0.35* 0.84* 0.20 0.40* 0.88* −0.13 −0.14  
Liver betaine 0.83* −0.34* 0.84* 0.27 −0.11 0.87* 0.08 0.28+ 0.97*
  1. aData from three transition cow studies were used for analysis [27, 28, 64]. In the study by Zhou et al. cows were fed a total mixed ration with or without rumen-protected Met (RPM) at 0.08% DM for 21 d prepartum and 30 d postpartum. Vailati-Riboni et al. fed diets with or without RPM at 0.10% DM for 28 d prepartum and 60 d postpartum. In the last study, a 2 × 2 factorial design of body condition score (BCS) and energy level during the peripartal period was used: 2 prepartum BCS categories [4.0 (thin, BCS 4) and 5.0 (optimal, BCS 5); 10-point scale] and 2 levels of energy intake during the 3 weeks. preceding calving (75% or 125% of estimated requirements) obtained via allowance (m2/cow) of fresh pasture composed of mostly perennial ryegrass and white clover. Due to the large range and distribution of the metabolomics data variables for liver Met and betaine, they were log-transformed. Values reported in the graphs are log values
  2. *P ≤ 0.05; +P ≤ 0.10
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