Table 5 Metabolic pathway enrichment analysis of significantly differential metabolites among health, subclinical mastitis and clinical mastitis cows
Groups | Metabolites | KEGG pathway | P-value | FDR |
|---|---|---|---|---|
CM/H | 10beta-Hydroxy-6beta-isobutyrylfuranoeremophilane | Limonene and pinene degradation | 3.09 × 10−6 | 0.008 |
12-Oxo-20-dihydroxy-leukotriene B4 | Arachidonic acid metabolism | 1.94 × 10− 5 | 0.026 | |
Methenamine | Formaldehyde biosynthesis | 3.25 × 10−5 | 0.036 | |
5-Hydroxymethyl-2-furancarboxaldehyde | Furfural degradation | 3.03 × 10−5 | 0.032 | |
6-Methoxymellein | Biosynthesis of plant secondary metabolites | 3.39 × 10−4 | 0.045 | |
2-Phenylbutyric acid | Butanoate metabolism | 6.62 × 10−4 | 0.042 | |
SM/H | Methenamine | Formaldehyde biosynthesis | 7.79 × 10−5 | 0.037 |
5-Hydroxymethyl-2-furancarboxaldehyde | Furfural degradation | 2.54 × 10−4 | 0.036 | |
6-Methoxymellein | Biosynthesis of plant secondary metabolites | 3.64 × 10−4 | 0.047 | |
Cinnamic acid | Phenylpropylene degradation | 7.58 × 10−4 | 0.058 | |
Lentialexin | Biosynthesis of plant secondary metabolites | 0.003 | 0.178 | |
CM/SM | 10beta-Hydroxy-6beta-isobutyrylfuranoeremophilane | Limonene and pinene degradation | 6.37 × 10−5 | 0.025 |
12-Oxo-20-dihydroxy-leukotriene B4 | Arachidonic acid metabolism | 7.34 × 10−5 | 0.029 | |
(3R,5Z)-5-Octene-1,3-diol | Fat hydrolysis | 9.54 × 10−4 | 0.063 | |
N-Acetylcadaverine | Lysine degradation | 1.06 × 10−4 | 0.034 |