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Fig. 8 | Journal of Animal Science and Biotechnology

Fig. 8

From: MiR-146a-5p targeting SMAD4 and TRAF6 inhibits adipogenensis through TGF-β and AKT/mTORC1 signal pathways in porcine intramuscular preadipocytes

Fig. 8

A model depicting the role of miR-146a-5p in regulating porcine IMF adipogenesis. The intramuscular preadipocytes are derived from the pig’s longest dorsal muscle. On the one hand, miR-146a-5p targets SMAD4 mRNA, inhibits the formation of signal transduction factors, inhibits TGF-β signal transmission into the nucleus, and inhibits cell proliferation by inhibiting cell cycle related genes. On the other hand, miR-146a-5p directly targets TRAF6 mRNA to inhibit its translation and inhibits adipogenesis gene expression through the AKT/mTORC1 signaling pathway, thereby inhibiting adipogenesis

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891