Fig. 4From: Time-restricted feeding downregulates cholesterol biosynthesis program via RORγ-mediated chromatin modification in porcine liver organoidsRORγ agonist rescues TRF-induced CHO downregulation. a Screening 20 compounds of lipid-related nuclear receptors for the rescue action on TRF-induced lower CHO content (mg/μg protein). b In line with the CHO content, SR0987 and desmosterol (RORγ agonists) rescued the CHO biosynthesis gene expression. c Pearson correlation analysis based on clinical data revealed that RORγ is positively correlated with CHO biosynthesis genes including MVK, FDPS, EBP and DHCR24. Data were presented as means ± SD of at least three independent experiments, *P < 0.05, using two tailed Student's t-test. Agonists were in red; antagonists were in blueBack to article page