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Table 6 Summary of studies in periparturient dairy cows investigating the effects of supplemental live yeast or yeast-based products on rumen epithelium, liver, colon, and plasma biomarkers

From: Role of nutraceuticals during the transition period of dairy cows: a review

Nutraceutical Treatment Period Tissue/Cells Main outcome Reference
Live yeast 1 × 1010/d/head From − 21 to 21 d relative to calving Rumen Dry cows responded rapidly to live yeast with Greater abundance of TLR4 and IL10 prepartum [124]
   Colon Greater abundance of DEFB1
Live yeast 2.5 g/d/head precalving and 10 g/d/head postcalving From −14 to 70 d relative to calving Liver Greater glycogen [109]
   Plasma Greater phosphorous concentration
Saccharomices cereviseae fermentation product 19 g/d/head From 28 to 42 d relative to calving Rumen Greater abundance of IGFBP6
In cows fed a high-starch diet increased abundance of BDH2
19 g/d/head From − 28 to 42 d relative to calving Plasma Lower haptoglobin at 7 d postpartum [115]
19 g/d/head From −29 to 42 d relative to calving Liver Tendency to increase PCK1 mRNA abundance [114]
   Liver Decreased cholesterol
   Plasma Increased cholesterol
56 or 112 g/d/head From −4 weeks to 4 weeks relative to calving Plasma Higher glucose between partum and + 3 d
Higher urea at partum and + 1 d.
With the dosage of 112 g/d/head, higher BHB at 3 d postpartum
Lower cortisol
  1. TLR4 toll-like receptor 4, IL10 interleukin 10, DEFB1 β-defensin, IGFBP6 insulin like growth factor binding protein 6, BDH2 3-hydroxybutyrate dehydrogenase 2, PCK1 phosphoenolpyruvate carboxykinase 1, BHB beta-hydroxybutyrate