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Table 8 Plasma concentrations of oxidized linoleic acid metabolites derived from multiple sources and ratios of select upstream:downstream metabolites in control ewes and ewes treated with 90 mg meloxicam on d 1 and 4 after lambing (mean ± SEM; μmol/L)

From: Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

    

P-values1

Oxylipid or Ratio2

CON

MEL

SEM

Trt

Cov

Cov × trt

Lambs

Hpcov × trt

9-HODE

52.5

44.9

4.2

NS

0.01

0.07

0.03

<  0.01

9-oxoODE

13.99

12.37

1.24

NS

NS

NS

0.01

0.02

13-HODE

133.0

124.8

8.45

NS

NS

<  0.01

NS

NS

13-oxoODE

1.90

2.55

0.31

NS

NS

NS

NS

NS

9-HODE:9-oxoODE3

3.35

3.59

0.17

NS

NS

0.06

0.06

<  0.10

13-HODE:13-oxoODE4

62.3

51.1

5.4

NS

NS

0.04

NS

NS

9,10-EpOME:9,10-DiHOME

0.37

0.46

0.03

0.06

–

–

–

–

  1. 1NS = P > 0.10
  2. 2HODE Hydroxyoctadecadienoic acid, oxoODE Oxooctadecadienoic acid, EpOME Epoxyoctadecenoic acid, DiHOME Dihydroxyoctadecenoic acid
  3. 3Cov × cov × trt: P = 0.06
  4. 4Cov × cov: P = 0.09; Cov × cov × trt: P = 0.04