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Table 6 Cytochrome P450-derived oxylipids in plasma in control ewes and ewes treated with 90 mg meloxicam on d 1 and 4 after lambing (mean ± SEM; μmol/L)

From: Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

     

P-values1

Oxylipid2

Substrate3

CON

MEL

SEM

Trt

Cov

Cov × cov

Cov × trt

Lambs

Hpcov × trt

9,10-EpOME

LA

8.20

8.12

0.52

NS

<  0.01

NS

NS

NS

0.03

9,10-DiHOME

LA

22.13

17.55

1.05

<  0.01

<  0.10

NS

0.03

0.02

NS

12,13-EpOME

LA

24.30

24.09

1.68

NS

–

–

–

–

–

20-HETE

ArA

5.15

5.26

0.48

NS

NS

NS

NS

NS

0.04

8,9-DHET4

ArA

1.11

0.36

0.19

0.04

0.10

0.04

NS

0.04

0.07

11,12-DHET

ArA

1.48

1.48

0.13

NS

0.10

NS

NS

NS

NS

14,15-DHET

ArA

2.72

2.47

0.15

NS

<  0.001

<  0.01

NS

0.07

0.03

14,15-DiHETE

EPA

5.64

5.06

0.38

NS

<  0.01

<  0.01

0.10

0.07

NS

17,18-DiHETE

EPA

45.16

39.07

2.35

0.07

<  0.001

<  0.001

NS

<  0.01

NS

19,20-EpDPE

DHA

3.29

4.06

0.51

NS

NS

–

–

–

–

19,20-DiHDPA

DHA

2.31

2.47

2.39

NS

<  0.01

0.02

NS

<  0.01

0.09

  1. 1NS = P > 0.10; Cov = d 1 covariate values
  2. 2EpOME Epoxyoctadecenoic acid, DiHOME Dihydroxyoctadecenoic acid, HETE Hydroxyeicosatetraenoic acid, DHET Dihydroxyeicosatrienoic acid, DiHETE Dihyroxy-eicosatetraenoic acid, EpDPE Epoxydocosapentaenoic acid, DiHDPA Dihydroxydocosapentaenoic acid
  3. 3LA Linoleic acid, ArA Arachidonic acid, EPA Eicosapentaenoic acid, DHA Docosahexaenoic acid
  4. 4Cov × cov × trt: P = 0.05
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Journal of Animal Science and Biotechnology

ISSN: 2049-1891