Journal of Animal Science and Biotechnology

Table 6 Cytochrome P450-derived oxylipids in plasma in control ewes and ewes treated with 90 mg meloxicam on d 1 and 4 after lambing (mean ± SEM; μmol/L)

From: Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

					P-values¹
Oxylipid²	Substrate³	CON	MEL	SEM	Trt	Cov	Cov × cov	Cov × trt	Lambs	Hpcov × trt
9,10-EpOME	LA	8.20	8.12	0.52	NS	< 0.01	NS	NS	NS	0.03
9,10-DiHOME	LA	22.13	17.55	1.05	< 0.01	< 0.10	NS	0.03	0.02	NS
12,13-EpOME	LA	24.30	24.09	1.68	NS	–	–	–	–	–
20-HETE	ArA	5.15	5.26	0.48	NS	NS	NS	NS	NS	0.04
8,9-DHET⁴	ArA	1.11	0.36	0.19	0.04	0.10	0.04	NS	0.04	0.07
11,12-DHET	ArA	1.48	1.48	0.13	NS	0.10	NS	NS	NS	NS
14,15-DHET	ArA	2.72	2.47	0.15	NS	< 0.001	< 0.01	NS	0.07	0.03
14,15-DiHETE	EPA	5.64	5.06	0.38	NS	< 0.01	< 0.01	0.10	0.07	NS
17,18-DiHETE	EPA	45.16	39.07	2.35	0.07	< 0.001	< 0.001	NS	< 0.01	NS
19,20-EpDPE	DHA	3.29	4.06	0.51	NS	NS	–	–	–	–
19,20-DiHDPA	DHA	2.31	2.47	2.39	NS	< 0.01	0.02	NS	< 0.01	0.09

¹NS = P > 0.10; Cov = d 1 covariate values
²EpOME Epoxyoctadecenoic acid, DiHOME Dihydroxyoctadecenoic acid, HETE Hydroxyeicosatetraenoic acid, DHET Dihydroxyeicosatrienoic acid, DiHETE Dihyroxy-eicosatetraenoic acid, EpDPE Epoxydocosapentaenoic acid, DiHDPA Dihydroxydocosapentaenoic acid
³LA Linoleic acid, ArA Arachidonic acid, EPA Eicosapentaenoic acid, DHA Docosahexaenoic acid
⁴Cov × cov × trt: P = 0.05

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ISSN: 2049-1891

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