Fig. 3
Oxylipid biosynthesis by fatty acid substrate and pathway. The effect of MEL administration to ewes on d 1 and 4 after lambing on oxylipid concentrations are shown with decreases represented in red text with an asterisk (*) and treatment × haptoglobin covariate represented in blue text and with a hashtag (#). Oxylipids that were not detected are in gray. The symbol (•) denotes oxylipids that can also be derived via non-enzymatic oxidation. Abbreviations: CYP = cytochrome P450; DHET = dihydroxyeicosatrienoic acid; DiHDoHE = dihydroxydocosahexaenoic acid; DiHDPA = dihydroxydocosapentaenoic acid; DiHETE = dihydroxyeicosatetraenoic acid; DiHOME = dihydroxyoctadecenoic acid; EET = epoxyeicosatrienoic acid; EpDPE = epoxydocosapentaenoic acid; EpOME = epoxyoctadecenoic acid; LX = lipoxin; HDoHE = hydroxyl-docosahexaenoic acid; HETE = hydroxyeicosatetraenoic acid; HHTrE = hydroxyheptadecatrienoic acid; HODE = hydroxyoctadecadienoic acid; HOTrE = hydroxyoctadecatrienoic acid; LOX = lipoxygenase; NE = nonenzymatic oxidation; oxoODE = oxooctadecadienoic acid; PG = prostaglandin; RvD2 = resolvin; sEH = soluble epoxide hydrolase; TXB2 = thromboxane B2