Table 2 Uniquely regulated GO-biological processes of 2D organoids exposed to various protein sources. List of biological processes as analyzed in GeneAnalytics using the differentially expressed genes compared to medium control (MC)
From: Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers
Sl No. | Biological processes modulated in treatments compared to MC | Putative regulation of biological process |
|---|---|---|
CAS | ||
1 | Glutathione metabolic process | Down |
2 | Notochord development | Up |
3 | Microtubule-based movement | Up |
4 | Glutathione derivative biosynthetic process | Down |
5 | Cellular detoxification of nitrogen compound | Down |
SBM | ||
1 | Phosphatidylcholine biosynthetic process | Down |
2 | Triglyceride homeostasis | Down |
3 | Drug metabolic process | Down |
4 | Type I interferon signaling pathway | Up |
5 | Retinol metabolic process | Down |
6 | Hexose transport | Down |
7 | Lipoprotein metabolic process | Down |
8 | Retinoid metabolic process | Down |
SDPP | ||
1 | Nucleosome assembly | Up |
2 | Positive regulation of apoptotic process | Up |
3 | Positive regulation of cell migration | Up |
4 | Response to wounding | Up |
5 | Wound healing, spreading of cells | Up |
6 | Negative regulation of cell cycle | Up |
7 | DNA replication-independent nucleosome assembly | Up |
8 | Cellular response to organic cyclic compound | Up |
9 | Angiogenesis | Up |
10 | Telomere organization | Up |
11 | Response to virus | Up |
12 | Cytokinesis | Up |
13 | DNA replication-dependent nucleosome assembly | Up |
14 | DNA-templated transcription, initiation | Up |
15 | Response to hypoxia | Up |
16 | Positive regulation of fever generation | Up |
17 | Mitotic spindle midzone assembly | Up |
18 | Platelet degranulation | Up |
19 | Positive regulation of cytokinesis | Up |
20 | Chromatin silencing at RDNA | Up |
21 | Protein stabilization | Up |
22 | Protein localization to kinetochore | Up |
23 | Omega-hydroxylase P450 pathway | Up |
24 | Positive regulation of protein localization to nucleus | Up |
YMW | ||
1 | Cholesterol biosynthetic process | Down |
2 | Steroid metabolic process | Down |
3 | Response to drug | Down |
4 | Oxidation-reduction process | Up |
5 | Transmembrane transport | Down |
6 | Isoprenoid biosynthetic process | Down |
7 | Very long-chain fatty acid metabolic process | Down |
8 | CDP-choline pathway | Down |
9 | Long-chain fatty acid metabolic process | Down |
10 | Steroid hormone mediated signaling pathway | Down |
11 | Response to gamma radiation | Up |