Skip to main content

Table 5 List of certain long non-coding RNAs, and their role in mammalian spermatogenesis

From: Long noncoding RNAs: new insights in modulating mammalian spermatogenesis

LncRNA name

Length

Chromosomal location*

Function [Ref]

HongrES2

1.588 kb

Chr. 5

Responsible for normal sperm capacitation in the epididymis [88]

LncRNA-Dmrt1

Chr.5

Possibly involved in the switching between mitosis and meiosis of developing germ cell [88]

LncRNA H19

2.6 kb

Chr.7

Affects the expression of IGF-1R by regulating the IGF-1 pathway [5]

LncRNA Gm2044

1034 bp

Chr. 7

Inhibits Utf1 mRNA translation and plays a potential role in spermatogenesis [78]

Meiotic recombination hot spot1 locus (Mrhl)

2.4 kb

Chr. 8

Inhibits the Wnt signaling pathway during spermatogenesis by interacting with p68 in spermatogonia [89, 90]

Tesra

4435 bp

Chr.9

Activation of Prss42/Tessp-2 gene [82]

LncRNA-HSVIII

Chr.9

Participate in the activation of the Prss42/Tessp-2 gene promoter [82]

LncRNA033862

6384 bp

Regulates Gfra1 expression levels and spermatogonial stem cells fate [17]

LncRNA-Tcam1

2.4 kb

Chr.11

Important for the immune response during spermatogenesis [55]

Malat1

7 kb

Chr.11

Plays a potential cis-regulatory role of transcription [19]

AK015322

20.5 kb

Chr.12

Promotes the proliferation of spermatogonial stem cells [36]

LncRNA4667

1.3 kb

Chr.13

A marker for round spermatids identification in mice [55]

LncRNA HOTAIR

3.7 kb

Chr.15

Regulates HoxD genes expression in trans by interacting with chromatin modification complexes [28]

LncRNA Neat1

3.2 kb

Chr.19

Plays an important role in the maintenance and assembly of nuclear speckles of mammalian cells [90]

LncRNA Jpx

Chr.X

Regulates the X-chromosome inactivation (Xi) switch [91]

LncRNA Tsix

Chr.X

Regulates the X-chromosome activation (Xa) switch [91]

LncRNA Tsx

Chr.X

Involved in apoptosis in meiotic division during spermatogenesis [81]

LncRNA-Xist

⁓17 kb

Chr.X

Involved in X chromosome inactivation [81].

LncRNA NLC1- C

Has a potential role in male fertility and regulates miRNA expression [78]

LncRNA Spga

Involved in spermatogonial differentiation in vitro [60]

  1. * The chromosomal location is in the mouse genome