From: Long noncoding RNAs: new insights in modulating mammalian spermatogenesis
LncRNA name | Length | Chromosomal location* | Function [Ref] |
---|---|---|---|
HongrES2 | 1.588 kb | Chr. 5 | Responsible for normal sperm capacitation in the epididymis [88] |
LncRNA-Dmrt1 | – | Chr.5 | Possibly involved in the switching between mitosis and meiosis of developing germ cell [88] |
LncRNA H19 | 2.6 kb | Chr.7 | Affects the expression of IGF-1R by regulating the IGF-1 pathway [5] |
LncRNA Gm2044 | 1034 bp | Chr. 7 | Inhibits Utf1 mRNA translation and plays a potential role in spermatogenesis [78] |
Meiotic recombination hot spot1 locus (Mrhl) | ∼2.4 kb | Chr. 8 | Inhibits the Wnt signaling pathway during spermatogenesis by interacting with p68 in spermatogonia [89, 90] |
Tesra | 4435 bp | Chr.9 | Activation of Prss42/Tessp-2 gene [82] |
LncRNA-HSVIII | – | Chr.9 | Participate in the activation of the Prss42/Tessp-2 gene promoter [82] |
LncRNA033862 | 6384 bp | – | Regulates Gfra1 expression levels and spermatogonial stem cells fate [17] |
LncRNA-Tcam1 | 2.4 kb | Chr.11 | Important for the immune response during spermatogenesis [55] |
Malat1 | ∼7 kb | Chr.11 | Plays a potential cis-regulatory role of transcription [19] |
AK015322 | ∼20.5 kb | Chr.12 | Promotes the proliferation of spermatogonial stem cells [36] |
LncRNA4667 | 1.3 kb | Chr.13 | A marker for round spermatids identification in mice [55] |
LncRNA HOTAIR | ∼3.7 kb | Chr.15 | Regulates HoxD genes expression in trans by interacting with chromatin modification complexes [28] |
LncRNA Neat1 | 3.2 kb | Chr.19 | Plays an important role in the maintenance and assembly of nuclear speckles of mammalian cells [90] |
LncRNA Jpx | – | Chr.X | Regulates the X-chromosome inactivation (Xi) switch [91] |
LncRNA Tsix | – | Chr.X | Regulates the X-chromosome activation (Xa) switch [91] |
LncRNA Tsx | – | Chr.X | Involved in apoptosis in meiotic division during spermatogenesis [81] |
LncRNA-Xist | ⁓17 kb | Chr.X | Involved in X chromosome inactivation [81]. |
LncRNA NLC1- C | – | – | Has a potential role in male fertility and regulates miRNA expression [78] |
LncRNA Spga | – | – | Involved in spermatogonial differentiation in vitro [60] |