Table 2 Descriptions of widely used lncRNA databases

EVlncRNA, [39]

http://biophy.dzu.edu.cn/EVLncRNAs

It provides 77 species of functionally annotated long noncoding RNAs validated for disease specific roles through low put experiments and deals with evolution and disease association of lncRNAs.

LNCipedia [40]

https://lncipedia.org/

It is one of the lncRNA reference gene database containing a total of 127802 unique transcripts, 56946 unique genes, 2482 lncRNA articles and 1555 lncRNA annotated genes including their functional information.

NONCODE [41]

www.noncode.org/

It is one of the comprehensively compiled databases which is integrated database with complete collection and annotation of lncRNAs but doesn’t include tRNAs and rRNAs. This database contains 17 species and 73,372 lncRNAs as well as literatures and public data bases.

LncRNADisease [42]

http://cmbi.bjmu.edu.cn /lncrnadisease

It provides a systematic collection of lncRNA and circular RNA disease association, transcriptional regulation of lncRNAs, miRNAs and mRNAs. It is one of the important database used in the clinical application for lncRNAs related studies.

LncRBase [43]

http://bicresources.jcBose.ac.in/zhumur/

It is enriched resource of lncRNA transcripts of human (133,361 entries) and mouse (83,201 entries) of 14 distinct subtypes with 8507of mouse and 14,813 of human newly annotated noncoding RNAs, piwi interacting RNAs and microRNAs including their regulation and association with many other genomic elements.

LncRNAdb [44]

www.lncrnadb.org/

It is a database with comprehensive collection of lncRNAs with their information of biological functions in eukaryotes and regulatory role of messenger RNA. It contains most of the relevant information about the RNA, annotation, target tissues of expression and associated diseases.

LncCeRBase [45]

http://lnccerbase.it1004.com

This database is developed for the competing endogenous RNAs (ceRNAs) encompassing 432 interactions of lncRNA-miRNA-mRNA with 130, 214 and 245 of lncRNA, miRNA, and genes respectively. It also have interactions of lncRNA-miRNA-mRNA associated with signaling pathways to explore the lncRNA regulatory mechanisms. It is designed specifically to studied and validated human ceRNAs.

RNAcentral [46]

http://rnacentral.org

It is an integrated database that compiled sequences of noncoding RNA of all RNA types and organisms serving a single entry for all RNA sequence searches. This comprehensive database has 22 collaborating databases from specialized non-coding RNA resources.

LncRNome [47]

http://genome.igib. res.in/lncRNome

Provides an outlook on annotation of more than 18000 transcripts of the different classes of lncRNAs including the intergenic lncRNAs, antisense lncRNAs, intronic lncRNAs, overlapping lncRNAs and processed pseudogenes. It is designed to provide relevant information for human lncRNAs and their respective function. This database focuses on compiled information about sequence, structure, genomic loci, motifs, expression and associated diseases of lncRNAs.

NRED [48]

http://jsm-research.imb.uq.edu.au/NRED

It provides relevant information on gene expression of lncRNA in mammals especially in human and mouse. This database consists of microarray data and in situ hybridization data and serves as an important resource to the scientific community to study and understand the lncRNAs.