Item | DIM1 | SEM | ST1 | SEM | P-value | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | -10 | -3 | 3 | 17 |  | −0.5 | 0.5 | 1.5 | 2.5 | 3.5 | 4.5 | 5.5 | 6.5 |  | DIM | ST | ST×DIM |
Hematocrit, % | 27.5ab | 28.1a | 27.0bc | 26.3c | 0.5 | 28.4a | 28.4a | 26.8b | 26.6b | 26.7b | 26.8b | 26.9b | 27.1b | 0.5 | 0.008 | < 0.001 | 0.54 |
O2, mmol/L | 5.9 | 5.8 | 5.7 | 5.8 | 0.1 | 6.2a | 6.1a | 5.8b | 5.7b | 5.6b | 5.6b | 5.7b | 5.7b | 0.1 | 0.46 | < 0.001 | 0.64 |
CO2, mmol/L | 27.2b | 26.5c | 29.1a | 28.5a | 0.3 | 27.1d | 27.0d | 28.2b | 28.8a | 28.3b | 27.9bc | 27.8bc | 27.4cd | 0.3 | < 0.001 | < 0.001 | 0.008 |
Insulin, mmol/L | 62.2b | 46.3b | 90.3a | 107.9a | 7.7 | 29.9d | 224.7a | 90.9b | 90.0b | 66.1c | 42.6d | 39.9d | 29.3d | 10.1 | < 0.001 | < 0.001 | < 0.001 |
Urea, mmol/L | 3.7b | 3.9b | 3.3c | 6.2a | 0.2 | 4.4a | 4.3b | 4.3c | 4.3bc | 4.3bc | 4.3bc | 4.3c | 4.2d | 0.2 | < 0.001 | < 0.001 | 0.02 |
Essential AA, μmol/L | |||||||||||||||||
 Lys | 97.0b | 90.3b | 133.9a | 84.5b | 12.0 | 86.1d | 114.1ab | 112.1ab | 116.7a | 108.3b | 99.7c | 88.4d | 85.9d | 8.4 | 0.005 | < 0.001 | 0.77 |
 Met | 28.3 | 27.1 | 26.0 | 24.9 | 1.8 | 25.6d | 31.3a | 28.5b | 26.7cd | 27.5bc | 25.6d | 23.7e | 24.0de | 1.4 | 0.37 | < 0.001 | 0.68 |
 Thr | 174.3 | 189.6 | 180.7 | 163.3 | 14.1 | 163.4d | 185.5ab | 186.3ab | 190.0a | 184.0b | 177.8c | 166.7d | 162.1d | 11.9 | 0.17 | < 0.001 | 0.55 |
 Trp | 69.3a | 68.5a | 56.1b | 66.2a | 3.7 | 61.6d | 67.4ab | 68.0ab | 69.2a | 66.5bc | 64.8c | 61.9d | 60.8d | 3.5 | < 0.001 | < 0.001 | 0.38 |
 Ile | 166.2a | 158.5a | 108.2b | 118.7b | 6.2 | 126.5c | 147.0a | 143.3ab | 144.4ab | 141.0ab | 139.2b | 131.1c | 130.5c | 5.1 | < 0.001 | < 0.001 | 0.88 |
 Leu | 205.4a | 182.6b | 139.7c | 151.2c | 10.0 | 154.7c | 188.3a | 178.4b | 176.5b | 171.2b | 169.4b | 159.8c | 159.3c | 8.8 | < 0.001 | < 0.001 | 0.44 |
 Val | 340.2a | 290.3b | 266.5b | 266.4b | 14.5 | 271.4c | 307.5a | 304.1ab | 301.7ab | 295.5ab | 292.0b | 278.9c | 275.7c | 11.3 | < 0.001 | < 0.001 | 0.51 |
 His | 82.2 | 81.5 | 82.7 | 89.4 | 4.3 | 77.6c | 85.0ab | 87.7a | 88.3a | 87.4a | 86.3a | 80.9bc | 78.2c | 4.0 | 0.09 | < 0.001 | 0.71 |
 Phe | 107.2a | 103.6a | 84.3b | 102.8a | 5.4 | 88.3d | 102.9ab | 105.2ab | 106.8a | 103.8ab | 101.9b | 94.2c | 92.8cd | 5.1 | < 0.001 | < 0.001 | 0.82 |
Non-essential AA, μmol/L | |||||||||||||||||
 Ala | 545.8a | 562.5a | 478.4b | 473.1b | 28.7 | 454.5d | 545.1b | 580.8a | 548.0b | 531.7bc | 515.2c | 474.3d | 469.9d | 27.1 | < 0.001 | < 0.001 | 0.04 |
 Asn | 23.9a | 20.9b | 10.1c | 21.1b | 1.8 | 12.1f | 18.0d | 21.9bc | 25.0a | 22.7b | 20.6c | 16.6de | 15.0e | 1.7 | < 0.001 | < 0.001 | 0.03 |
 Asp | 41.8b | 40.0b | 46.7a | 49.1a | 2.1 | 36.7e | 43.8cd | 47.3b | 51.4a | 48.8b | 46.7bc | 42.0d | 38.4e | 1.8 | 0.001 | < 0.001 | 0.57 |
 Cys | 205.9b | 204.6b | 260.5a | 200.8b | 7.9 | 223.0a | 225.6a | 215.1b | 215.2b | 216.2b | 214.7b | 216.4b | 217.5b | 6.1 | < 0.001 | < 0.001 | 0.33 |
 Glu | 254.1ab | 234.6bc | 269.3a | 225.5c | 13.5 | 230.3c | 250.6ab | 255.7a | 253.5a | 251.0a | 249.3ab | 239.7bc | 236.7c | 10.5 | 0.01 | < 0.001 | 0.09 |
 Gly | 821.7 | 855.2 | 778.2 | 781.5 | 30.0 | 793.6de | 799.2de | 780.3e | 822.2bc | 838.0a | 828.1ab | 810.1cd | 801.7cde | 16.9 | 0.16 | < 0.001 | < 0.001 |
 Pro | 501.4a | 475.5a | 320.3c | 416.4b | 26.5 | 371.4e | 417.5cd | 444.1ab | 460.0a | 455.6a | 450.1a | 427.5bc | 401.0de | 21.3 | < 0.001 | < 0.001 | 0.45 |
 Ser | 147.7a | 142.1a | 125.2b | 140.8a | 6.2 | 130.4c | 146.1a | 139.0bc | 144.6a | 143.3ab | 140.8ab | 134.6c | 132.9c | 4.8 | 0.010 | < 0.001 | 0.01 |
 Tyr | 120.6ab | 115.0b | 89.2c | 124.7a | 5.8 | 103.3d | 117.4ab | 117.7ab | 120.1a | 116.5b | 113.8b | 107.0c | 103.4d | 5.3 | < 0.001 | < 0.001 | 0.44 |
 Gln | 276.2c | 241.5d | 344.2b | 374.3a | 14.1 | 290.0c | 308.6b | 318.0b | 339.2a | 338.1a | 317.0b | 290.2c | 271.4d | 13.1 | < 0.001 | < 0.001 | 0.33 |