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Fig. 10 | Journal of Animal Science and Biotechnology

Fig. 10

From: Evaluation of heat stress effects on cellular and transcriptional adaptation of bovine granulosa cells

Fig. 10

Research review: Mechanisms of regulating heat stress response related to follicular function within bovine ovary. Upregulated genes caspase-3, SOD, BCL-2, BAX, and HSPs (HSP70, HSPA13, HMOX1) were involved in the regulating mechanism of bGCs via induced or inhibited cell apoptosis. Under heat stress, Down-regulated genes CAT, FOXO3 were involved in production of reactive oxygen species (ROS). Likewise, down-regulation of STAR, and CYP11A1 were involved in the secretion of E2 and P4. Moreover, the decline of E2, and enhancing of ROS in turn, might enhance the possibility of GC apoptosis and follicle function

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