Fig. 10

Research review: Mechanisms of regulating heat stress response related to follicular function within bovine ovary. Upregulated genes caspase-3, SOD, BCL-2, BAX, and HSPs (HSP70, HSPA13, HMOX1) were involved in the regulating mechanism of bGCs via induced or inhibited cell apoptosis. Under heat stress, Down-regulated genes CAT, FOXO3 were involved in production of reactive oxygen species (ROS). Likewise, down-regulation of STAR, and CYP11A1 were involved in the secretion of E₂ and P₄. Moreover, the decline of E₂, and enhancing of ROS in turn, might enhance the possibility of GC apoptosis and follicle function