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Table 3 Differentially expressed genes (P-value < 0.01 and fold-change ≥ or ≤ 1.5) associated with glycolysis and gluconeogenesis in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

Symbol

Description

KET vs. OVE

P value

FBP2

Fructose-1,6-bisphosphatase 2

−8.60

0.003

PDK4

Pyruvate dehydrogenase kinase 4

−3.35

0.028

PDK2

Pyruvate dehydrogenase kinase, isozyme 2

−2.27

0.018

PFKL

Phosphofructokinase, liver

−1.57

0.015

PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

1.80

0.047

PCCA

Propionyl CoA carboxylase, alpha polypeptide

1.70

0.020

PDHB

Pyruvate dehydrogenase (lipoamide) beta (PDHB)

1.51

0.045

PCK1

Phosphoenolpyruvate carboxykinase 1 (soluble)

1.51

0.035