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Table 3 Differentially expressed genes (P-value < 0.01 and fold-change ≥ or ≤ 1.5) associated with glycolysis and gluconeogenesis in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

Symbol Description KET vs. OVE P value
FBP2 Fructose-1,6-bisphosphatase 2 −8.60 0.003
PDK4 Pyruvate dehydrogenase kinase 4 −3.35 0.028
PDK2 Pyruvate dehydrogenase kinase, isozyme 2 −2.27 0.018
PFKL Phosphofructokinase, liver −1.57 0.015
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1.80 0.047
PCCA Propionyl CoA carboxylase, alpha polypeptide 1.70 0.020
PDHB Pyruvate dehydrogenase (lipoamide) beta (PDHB) 1.51 0.045
PCK1 Phosphoenolpyruvate carboxykinase 1 (soluble) 1.51 0.035