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Table 3 Differentially expressed genes (P-value < 0.01 and fold-change ≥ or ≤ 1.5) associated with glycolysis and gluconeogenesis in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

SymbolDescriptionKET vs. OVEP value
FBP2Fructose-1,6-bisphosphatase 2−8.600.003
PDK4Pyruvate dehydrogenase kinase 4−3.350.028
PDK2Pyruvate dehydrogenase kinase, isozyme 2−2.270.018
PFKLPhosphofructokinase, liver−1.570.015
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 21.800.047
PCCAPropionyl CoA carboxylase, alpha polypeptide1.700.020
PDHBPyruvate dehydrogenase (lipoamide) beta (PDHB)1.510.045
PCK1Phosphoenolpyruvate carboxykinase 1 (soluble)1.510.035