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Table 2 Differentially expressed genes with a P-value < 0.01 and fold change ≤ − 4 in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

SymbolDescriptionKET vs. OVE
DOCK3Dedicator of cytokinesis 3−8.12
FAM131AFamily with sequence similarity 131, member A−6.91
LOC528412Multidrug resistance-associated protein 4−6.80
COBRA1Cofactor of BRCA1−6.24
CPXM2Carboxypeptidase X (M14 family), member 2−6.13
UNC13DUnc-13 homolog D (C. elegans)−5.18
LOC780781Keratin associated protein−5.11
BTBD10BTB (POZ) domain containing 10−5.09
BADBCL2-associated agonist of cell death−5.08
NEU4Sialidase 4−5.08
SS18Synovial sarcoma translocation, chromosome 18−4.82
TAPBPLTAP binding protein-like−4.80
KIAA0922KIAA0922 ortholog−4.77
APOBRApolipoprotein B receptor−4.68
PROK2Prokineticin 2−4.64
WDR6WD repeat domain 6−4.60
EVC2Ellis van creveld syndrome 2−4.58
SYN3Synapsin III−4.50
GLCCI1Glucocorticoid induced transcript 1−4.50
DLGAP5Discs, large (Drosophila) homolog-associated protein 5−4.47
CIB2Calcium and integrin binding family member 2−4.47
TBC1D19TBC1 domain family, member 19−4.41
ARNTAryl hydrocarbon receptor nuclear translocator−4.40
ACPTAcid phosphatase, testicular−4.40
MAPK3Mitogen-activated protein kinase 3−4.39
TUBG1Tubulin, gamma 1−4.39
NCOA2Nuclear receptor coactivator 2−4.29
DSTPredicted: Dystonin, transcript variant 1−4.23
PTK2PTK2 protein tyrosine kinase 2−4.21
HCN1Hyperpolarization activated cyclic nucleotide-gated potassium channel 1−4.20
DEFB1Defensin, beta 1−4.16
TTF2Transcription termination factor, RNA polymerase II−4.13
NPBNeuropeptide B−4.13
RAB27ARAB27A, member RAS oncogene family−4.09
ZYG11AZyg-11 homolog A (C. elegans)−4.08
MAP3K4Mitogen-activated protein kinase kinase kinase 4−4.06
TPGS1Predicted: Chromosome 7 open reading frame, human C19orf20−4.04
C1QTNF3C1q and tumor necrosis factor related protein 3−4.00