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Table 2 Differentially expressed genes with a P-value < 0.01 and fold change ≤ − 4 in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

Symbol Description KET vs. OVE
DOCK3 Dedicator of cytokinesis 3 −8.12
FAM131A Family with sequence similarity 131, member A −6.91
LOC528412 Multidrug resistance-associated protein 4 −6.80
COBRA1 Cofactor of BRCA1 −6.24
CPXM2 Carboxypeptidase X (M14 family), member 2 −6.13
UNC13D Unc-13 homolog D (C. elegans) −5.18
LOC780781 Keratin associated protein −5.11
BTBD10 BTB (POZ) domain containing 10 −5.09
BAD BCL2-associated agonist of cell death −5.08
NEU4 Sialidase 4 −5.08
SS18 Synovial sarcoma translocation, chromosome 18 −4.82
TAPBPL TAP binding protein-like −4.80
KIAA0922 KIAA0922 ortholog −4.77
APOBR Apolipoprotein B receptor −4.68
PROK2 Prokineticin 2 −4.64
WDR6 WD repeat domain 6 −4.60
EVC2 Ellis van creveld syndrome 2 −4.58
SYN3 Synapsin III −4.50
GLCCI1 Glucocorticoid induced transcript 1 −4.50
DLGAP5 Discs, large (Drosophila) homolog-associated protein 5 −4.47
CIB2 Calcium and integrin binding family member 2 −4.47
TBC1D19 TBC1 domain family, member 19 −4.41
ARNT Aryl hydrocarbon receptor nuclear translocator −4.40
ACPT Acid phosphatase, testicular −4.40
MAPK3 Mitogen-activated protein kinase 3 −4.39
TUBG1 Tubulin, gamma 1 −4.39
NCOA2 Nuclear receptor coactivator 2 −4.29
REN Renin −4.25
DST Predicted: Dystonin, transcript variant 1 −4.23
PTK2 PTK2 protein tyrosine kinase 2 −4.21
HCN1 Hyperpolarization activated cyclic nucleotide-gated potassium channel 1 −4.20
DEFB1 Defensin, beta 1 −4.16
TTF2 Transcription termination factor, RNA polymerase II −4.13
NPB Neuropeptide B −4.13
RAB27A RAB27A, member RAS oncogene family −4.09
ZYG11A Zyg-11 homolog A (C. elegans) −4.08
MAP3K4 Mitogen-activated protein kinase kinase kinase 4 −4.06
TPGS1 Predicted: Chromosome 7 open reading frame, human C19orf20 −4.04
C1QTNF3 C1q and tumor necrosis factor related protein 3 −4.00