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Table 1 Differentially expressed genes with a P-value < 0.01 and fold change ≥3 in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

SymbolDescriptionKET vs. OVE
CCL2Chemokine (C-C motif) ligand 2 (CCL2)5.12
CLCA2Chloride channel accessory 25.09
CACNA1DCalcium channel, voltage-dependent4.51
ADARB2Adenosine deaminase, RNA-specific4.51
KRT9Keratin 94.45
KIFC2Kinesin family member C24.34
MARK1MAP/microtubule affinity-regulating kinase 14.22
POLE2Polymerase (DNA directed), epsilon 2 (p59 subunit)4.19
SLC22A2Solute carrier family 22 (organic cation transporter), member 24.06
GPR63G protein-coupled receptor 633.98
ANO3Anoctamin 33.88
XKX-linked Kx blood group (McLeod syndrome)3.83
DUSP4Dual specificity phosphatase 43.73
SPATA7Spermatogenesis associated 73.64
ZC3H4Zinc finger CCCH-type containing 43.59
SYCE3Synaptonemal complex central element protein 33.57
MYRIPMyosin VIIA and Rab interacting protein3.40
LOC787081Predicted: UPF0632 protein A3.36
CNR1Cannabinoid receptor 1 (brain)3.21
SPATA17Predicted: spermatogenesis associated 173.20
PCBP3Poly(rC) binding protein 3 (PCBP3)3.09
ADAM32ADAM metallopeptidase domain 32 (ADAM32)3.08