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Table 1 Differentially expressed genes with a P-value < 0.01 and fold change ≥3 in liver tissue harvested 10 days prior to parturition from Holstein cows with (KET) or without (OVE) clinical ketosis during the first week postpartum. Both groups of cows were fed a diet containing 1.54 Mcal/kg of dry matter and 15.0% crude protein from − 21 days prepartum to calving, and a common lactation diet containing 1.75 Mcal/kg of dry matter and 17.5% crude protein

From: Hepatic metabolomics and transcriptomics to study susceptibility to ketosis in response to prepartal nutritional management

Symbol Description KET vs. OVE
CCL2 Chemokine (C-C motif) ligand 2 (CCL2) 5.12
CLCA2 Chloride channel accessory 2 5.09
CACNA1D Calcium channel, voltage-dependent 4.51
ADARB2 Adenosine deaminase, RNA-specific 4.51
KRT9 Keratin 9 4.45
KIFC2 Kinesin family member C2 4.34
MARK1 MAP/microtubule affinity-regulating kinase 1 4.22
POLE2 Polymerase (DNA directed), epsilon 2 (p59 subunit) 4.19
SLC22A2 Solute carrier family 22 (organic cation transporter), member 2 4.06
GPR63 G protein-coupled receptor 63 3.98
ANO3 Anoctamin 3 3.88
XK X-linked Kx blood group (McLeod syndrome) 3.83
DUSP4 Dual specificity phosphatase 4 3.73
SPATA7 Spermatogenesis associated 7 3.64
ZC3H4 Zinc finger CCCH-type containing 4 3.59
SYCE3 Synaptonemal complex central element protein 3 3.57
MYRIP Myosin VIIA and Rab interacting protein 3.40
LOC787081 Predicted: UPF0632 protein A 3.36
CNR1 Cannabinoid receptor 1 (brain) 3.21
SPATA17 Predicted: spermatogenesis associated 17 3.20
PCBP3 Poly(rC) binding protein 3 (PCBP3) 3.09
ADAM32 ADAM metallopeptidase domain 32 (ADAM32) 3.08