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Fig. 2 | Journal of Animal Science and Biotechnology

Fig. 2

From: Clostridium species as probiotics: potentials and challenges

Fig. 2

The interaction between F. prausnitzii and colonic immune. F. prausnitzii could exert anti-inflammation effects to our health dependent on its interaction with colonic immune to a great extent. 1) Salicylic acid could be produced from salicin fermentation by 40% F. prausnitzii and block the production of IL8 [28]. 2) F. prausnitzii and its culture supernatant could exhibit anti-inflammatory effects via IL10 production from Treg cells [19]. 3) CCR6+ CXCR6+ DP8α T cells are a new gut-derived TREG cell subpopulation. They can particularly response to F. prausnitzii and exert anti-inflammation effect by promoting the IL10 production dependent on CD39 [23]. 4) Extracellular polymeric matrix (EPM) of F. prausnitzii strain HTF-F induced the TLR2-dependent secretion of IL10 and IL12 in human monocyte-derived dendritic cells (DC cells) to attenuate inflammation [24]

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