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Table 3 Associations of the SNPs in PIK3R1 and DUSP1 genes with milk production traits in two lactations in Chinese Holstein (LSM ± SE)

From: Identification of single nucleotide polymorphisms of PIK3R1 and DUSP1 genes and their genetic associations with milk production traits in dairy cows

Gene SNP Lactation Genotype(n) Milk yield, kg Fat yield, kg Fat percentage, % Protein yield, kg Protein percentage, %
PIK3R1 rs42590258 1 AA (135) 10,462 ± 86.13a 349.88 ± 3.66a 3.35 ± 0.04 306.8 ± 2.67 2.93 ± 0.01Aa
AG (473) 10,266 ± 65.34b 343.3 ± 2.9ab 3.36 ± 0.03 303.29 ± 2.11 2.96 ± 0.01ab
GG (428) 10,314 ± 65.48ab 342.19 ± 2.91b 3.33 ± 0.03 305.32 ± 2.12 2.96 ± 0.01Bb
P value 0.0373 0.0461 0.3398 0.1916 0.0131
2 AA (99) 10,959 ± 98.39a 391.1 ± 4.16ab 3.59 ± 0.04 324.99 ± 3.03 2.97 ± 0.01
AG (328) 10,751 ± 68.47ab 391.5 ± 3.02Aa 3.65 ± 0.03 318.46 ± 2.2 2.97 ± 0.01
GG (297) 10,695 ± 69.91b 383.63 ± 3.08Bb 3.6 ± 0.03 318.94 ± 2.24 2.99 ± 0.01
P value 0.0233 0.0065 0.0538 0.0541 0.0979
rs210389799 1 CC (70) 10,283 ± 104.72 338.75 ± 4.38 3.31 ± 0.04 301.96 ± 3.19 2.94 ± 0.01
TC (427) 10,362 ± 67.57 342.2 ± 2.99 3.31 ± 0.03 305.69 ± 2.18 2.95 ± 0.01
TT (548) 10,381 ± 63.46 345.82 ± 2.83 3.34 ± 0.03 306.91 ± 2.06 2.96 ± 0.01
P value 0.5914 0.0705 0.2506 0.1953 0.4421
2 CC (55) 10,619 ± 119.13 380.41 ± 4.96 3.62 ± 0.05 314 ± 3.62 2.96 ± 0.02
TC (287) 10,770 ± 72.29 385.05 ± 3.18 3.59 ± 0.03 320.02 ± 2.32 2.98 ± 0.01
TT (384) 10,685 ± 65.96 384.05 ± 2.94 3.62 ± 0.03 317.03 ± 2.14 2.98 ± 0.01
P value 0.2598 0.6072 0.6018 0.1141 0.5929
rs208819656 1 CC (72) 10,185 ± 102.59 337.79 ± 4.42ab 3.34 ± 0.04 297.83 ± 3.25Aa 2.96 ± 0.01
CT (419) 10,298 ± 66.79 339.69 ± 2.99a 3.32 ± 0.03 303.08 ± 2.19ab 2.95 ± 0.01
TT (516) 10,332 ± 63.92 344.74 ± 2.87b 3.35 ± 0.03 305.28 ± 2.09Bb 2.96 ± 0.01
P value 0.2816 0.0272 0.2915 0.0258 0.3219
2 CC (58) 10,537 ± 117.02a 389.48 ± 3.43 3.62 ± 0.05 312.93 ± 3.57a 2.97 ± 0.02
CT (286) 10,822 ± 72.57b 391.17 ± 3.04 3.61 ± 0.03 321.96 ± 2.32b 2.98 ± 0.01
TT (376) 10,694 ± 67.37ab 387.81 ± 3.35 3.62 ± 0.03 317.97 ± 2.19ab 2.98 ± 0.01
P value 0.0207 0.5115 0.7832 0.0117 0.8131
rs41255622 1 AA (231) 10,265 ± 72.87a 338.83 ± 3.17a 3.32 ± 0.03 302.24 ± 2.31Aa 2.95 ± 0.01
AT (508) 10,309 ± 64.3a 342.69 ± 2.86ab 3.34 ± 0.03 304.52 ± 2.08a 2.96 ± 0.01
TT (270) 10,449 ± 70.93b 346.79 ± 3.11b 3.33 ± 0.03 308.75 ± 2.26Bb 2.96 ± 0.01
P value 0.013 0.0135 0.7073 0.0032 0.7936
2 AA (174) 10,845 ± 76.65 384.11 ± 3.33 3.63 ± 0.03 320.8 ± 2.5 2.98 ± 0.01
AT (354) 10,737 ± 69.06 386.59 ± 3.06 3.64 ± 0.03 319.91 ± 2.21 2.98 ± 0.01
TT (196) 10,670 ± 78.59 381.95 ± 3.4 3.6 ± 0.03 320.73 ± 2.44 2.97 ± 0.01
P value 0.1056 0.2695 0.428 0.8883 0.5442
rs133655926 1 CC (275) 10,451 ± 70.63a 347.43 ± 3.1a 3.34 ± 0.03 307.9 ± 2.25a 2.95 ± 0.01
TC (519) 10,313 ± 64.02b 343.66 ± 2.85ab 3.35 ± 0.03 304.46 ± 2.08ab 2.96 ± 0.01
TT (229) 10,295 ± 73.94ab 340.67 ± 3.22b 3.33 ± 0.03 303.06 ± 2.34b 2.95 ± 0.01
P value 0.0267 0.0437 0.6163 0.0358 0.6543
2 CC (200) 10,845 ± 76.65 384.11 ± 3.33 3.57 ± 0.03 320.18 ± 2.42 2.96 ± 0.01
TC (358) 10,737 ± 69.06 386.59 ± 3.06 3.62 ± 0.03 318.32 ± 2.23 2.97 ± 0.01
TT (173) 10,670 ± 78.59 381.95 ± 3.4 3.6 ± 0.03 316.28 ± 2.48 2.97 ± 0.01
P value 0.1056 0.2695 0.2678 0.2898 0.6173
rs211408208 1 AA (69) 10,135 ± 105.87 339.36 ± 4.59ab 3.37 ± 0.04 297.57 ± 3.24 2.95 ± 0.01
AG (419) 10,252 ± 67.09 342.8 ± 3.04a 3.34 ± 0.03 301.17 ± 2.16 2.95 ± 0.01
GG (508) 10,260 ± 63.18 348.14 ± 2.86b 3.37 ± 0.03 302.97 ± 2.05 2.96 ± 0.01
P value 0.4168 0.0111 0.2459 0.1178 0.1653
2 AA (57) 10,713 ± 117 385.34 ± 4.88 3.61 ± 0.05 317.64 ± 3.56 2.96 ± 0.02
AG (286) 10,859 ± 72.14 389.01 ± 3.16 3.59 ± 0.03 322.05 ± 2.3 2.97 ± 0.01
GG (371) 10,743 ± 66.59 386.73 ± 2.96 3.62 ± 0.03 317.79 ± 2.16 2.97 ± 0.01
P value 0.1481 0.5837 0.6063 0.0645 0.871
DUSP1 rs207593520 1 GG (128) 10,310 ± 87.86 337.1 ± 3.75a 3.27 ± 0.04 304.66 ± 2.73 2.95 ± 0.01ab
GT (444) 10,372 ± 65.07 344.51 ± 2.89b 3.33 ± 0.03 305.05 ± 2.1 2.94 ± 0.01a
TT (431) 10,397 ± 65.53 345.64 ± 2.91b 3.34 ± 0.03 307.76 ± 2.12 2.96 ± 0.01b
P value 0.5322 0.0201 0.1115 0.1487 0.026
2 GG (99) 11,256 ± 98.44A 395.73 ± 4.18Aa 3.65 ± 0.04 323.58 ± 3.05a 2.97 ± 0.01
GT (303) 10,964 ± 69.52Bb 384.24 ± 3.08Bb 3.59 ± 0.03 318.36 ± 2.24ab 2.97 ± 0.01
TT (310) 10,833 ± 71.81Bb 385.59 ± 3.14b 3.61 ± 0.03 316.61 ± 2.29b 2.97 ± 0.01
P value <.0001 0.0073 0.2932 0.0418 0.7827
rs208460068 1 AA (76) 10,603 ± 105.06a 347.69 ± 4.41 3.29 ± 0.04 313.22 ± 3.21a 2.96 ± 0.01
AG (473) 10,354 ± 65.04b 344.92 ± 2.88 3.35 ± 0.03 305 ± 2.1Bb 2.95 ± 0.01
GG (467) 10,369 ± 64.51b 343.71 ± 2.86 3.33 ± 0.03 306.61 ± 2.08ab 2.96 ± 0.01
P value 0.0338 0.5601 0.2866 0.0132 0.2481
2 AA (59) 11,344 ± 118.56A 399.21 ± 4.95Aa 3.54 ± 0.05 336.32 ± 3.61A 2.97 ± 0.02
AG (332) 10,842 ± 68.11B 392.67 ± 3.01Aa 3.62 ± 0.03 321.62 ± 2.19B 2.97 ± 0.01
GG (339) 10,617 ± 69.61C 382.41 ± 3.08B 3.62 ± 0.03 315.07 ± 2.24C 2.97 ± 0.01
P value <.0001 <.0001 0.2052 <.0001 0.969
rs209154772 1 CC (466) 10,307 ± 64.33a 341.63 ± 2.86 3.33 ± 0.03 305.42 ± 2.08a 2.96 ± 0.01
TC (458) 10,316 ± 64.98a 344.11 ± 2.88 3.35 ± 0.03 304.36 ± 2.1Aa 2.95 ± 0.01
TT (91) 10,552 ± 98.79b 345.62 ± 4.16 3.29 ± 0.04 312.43 ± 3.03Bb 2.96 ± 0.01
P value 0.0203 0.3403 0.1808 0.0089 0.1257
2 CC (339) 10,639 ± 69.67Aa 384.61 ± 3.08Aa 3.63 ± 0.03 316.76 ± 2.24Aa 2.98 ± 0.01
TC (318) 10,794 ± 68.91Ab 391.15 ± 3.04c 3.63 ± 0.03 320.77 ± 2.22Aa 2.98 ± 0.01
TT (70) 11,295 ± 111.38B 401.97 ± 4.67Bb 3.58 ± 0.05 334.82 ± 3.41B 2.97 ± 0.02
P value <.0001 0.0001 0.4368 <.0001 0.6954
rs210000760 1 CC (462) 10,343 ± 64.92a 345.15 ± 2.89 3.35 ± 0.03 306.37 ± 2.1a 2.96 ± 0.01
CG (458) 10,319 ± 64.75Aa 346.4 ± 2.87 3.37 ± 0.03 304.42 ± 2.09Aa 2.95 ± 0.01
GG (91) 10,585 ± 98.43Bb 348.72 ± 4.15 3.3 ± 0.04 312.86 ± 3.02Bb 2.95 ± 0.01
P value 0.0118 0.5743 0.1534 0.0052 0.1864
2 CC (340) 10,614 ± 69.01A 385.45 ± 3.05Aa 3.64 ± 0.03 316.05 ± 2.22Aa 2.98 ± 0.01
CG (319) 10,826 ± 68.53B 392.49 ± 3.03b 3.63 ± 0.03 321.5 ± 2.2Ab 2.98 ± 0.01
GG (71) 11,302 ± 109.96C 401.5 ± 4.61Bb 3.57 ± 0.04 335.23 ± 3.36B 2.97 ± 0.02
P value <.0001 0.0003 0.2737 <.0001 0.8597
  1. Note: The number in the bracket represents the number of cows for the corresponding genotype; P value shows the significance for the genetic effects of SNPs; a, b, c within the same column with different superscripts means P value < 0.05; A, B, C within the same column with different superscripts means P value < 0.01