Fig. 6

The targeting regulatory network of miRNA-circRNA centered on miRNA-449a and circRNA8077. Note: the yellow double triangle in middle place was the miRNA-449a (a) and circRNA8077 (b), blue triangle nodes represent circRNAs what were the targets predicted by two publicly available programs (Targetscan 7.0 and miRanda), and red nodes represent miRNAs what were found differentially expressed in PE and RE. The more edges a circRNA has, the more miRNAs that interact with it, and the more central a role it had within the network