Fig. 4
From: Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation
Targeting MSTN promoter. Schematic representation of potential mechanisms to modulate MSTN promoter activity for medical and breeding purposes. a The use of SIRT6 [103], PDA [36], ursolic Acid [105] and a specific promoter siRNA [104] were suggested to downregulate MSTN promoter activity to ameliorate muscle wasting; b Promoter trap vector was used to produce bovine cells with GFP/Neomycin genes downstream of the MSTN promoter, in place of the MSTN gene [107]