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Table 6 Fatty acid composition of lung parenchymal tissue and porcine alveolar macrophages (PAM)1–2

From: Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages

Tissue

Lung

PAM

Diet

CON

LC n-6

LC n-3

P - value

CON

LC n-6

LC n-3

P - value

Fatty acid, g/100 g FA

14:0

1.62 ± 0.44

1.81 ± 0.38

2.04 ± 0.24

0.68

1.66 ± 0.19

1.53 ± 0.22

1.93 ± 0.22

0.45

16:0

31.38 ± 1.20

33.13 ± 1.04

33.45 ± 0.66

0.33

38.48 ± 3.31

33.62 ± 3.82

32.71 ± 3.82

0.47

16:1

0.66 ± 0.04 a

0.50 ± 0.04 b

0.50 ± 0.02 b

0.01

0.82 ± 0.13

0.46 ± 0.15

0.74 ± 0.15

0.22

18:0

20.56 ± 1.29

19.01 ± 1.12

20.23 ± 0.71

0.59

24.31 ± 1.65

25.44 ± 1.90

21.38 ± 1.90

0.32

18:1

22.94 ± 1.02

21.85 ± 0.88

22.82 ± 0.56

0.61

14.43 ± 1.18

13.02 ± 1.34

17.71 ± 1.34

0.06

18:2

10.06 ± 0.54 a

8.21 ± 0.47 b

10.83 ± 0.30 a

0.0002

5.76 ± 0.73xy

5.22 ± 0.84x

8.11 ± 0.84y

0.06

18:3 (n-6)

0.12 ± 0.03 a

0.02 ± 0.03 b

0.00 ± 0.02 b

0.01

1.25 ± 0.19

1.48 ± 0.22

1.23 ± 0.22

0.67

18:3 (n-3)

0.22 ± 0.07

0.17 ± 0.06

0.16 ± 0.04

0.76

0.03 ± 0.04x

0.00 ± 0.04x

0.17 ± 0.04y

0.02

20:0

0.40 ± 0.09

0.45 ± 0.07

0.45 ± 0.05

0.86

0.58 ± 0.08

0.38 ± 0.09

0.55 ± 0.09

0.27

20:1

0.43 ± 0.05 a

0.28 ± 0.04 b

0.30 ± 0.03 b

0.03

0.47 ± .09

0.23 ± 0.10

0.47 ± 0.10

0.16

20:2

0.7 ± 0.053a

0.56 ± 0.04 b

0.50 ± 0.03 b

0.001

0.73 ± 0.12

0.58 ± 0.14

0.34 ± 0.14

0.15

20:4 (n-6)

8.26 ± 0.60 a

11.55 ± 0.52 b

4.56 ± 0.33 c

< 0.0001

7.66 ± 1.40x

14.22 ± 1.62y

6.27 ± 1.62x

0.01

20:3 (n-3)

0.62 ± 0.08

0.43 ± 0.07

0.60 ± 0.04

0.10

0.70 ± 0.11

0.67 ± 0.12

0.57 ± 0.12

0.74

20:5 (n-3)

0.00 ± 0.15a

0.00 ± 0.13a

1.53 ± 0.08b

<  0.0001

0.02 ± 0.28x

0.00 ± 0.33 x

3.44 ± 0.33y

<  0.0001

22:0

0.68 ± 0.19

0.69 ± 0.16

0.85 ± 0.10

0.60

1.90 ± 0.18

1.81 ± 0.21

1.88 ± 0.20

0.95

22:1

0.60 ± 0.22

0.73 ± 0.19

0.56 ± 0.12

0.74

0.02 ± 0.05x

0.00 ± 0.06x

0.23 ± 0.06y

0.03

22:6 (n-3)

0.63 ± 0.11

0.63 ± 0.10

0.62 ± 0.06

0.99

1.19 ± 0.26x

1.34 ± 0.30x

2.27 ± 0.30y

0.04

Total

100

100

100

 

100

100

100

 

MUFA

24.63 ± 1.11

23.36 ± 0.96

24.18 ± 0.61

0.67

15.73 ± 1.32

13.72 ± 1.50

19.15 ± 1.50

0.06

PUFA

20.65 ± 1.17

21.57 ± 1.02

18.80 ± 0.64

0.07

17.34 ± 2.23

23.50 ± 2.76

22.41 ± 2.76

0.21

n-3 FA

1.47 ± 0.31a

1.23 ± 0.27a

2.91 ± 0.17b

< 0.0001

1.94 ± 0.63x

2.01 ± 0.57x

6.45 ± 0.57y

< 0.0001

n-6 FA

19.18 ± 0.94a

20.34 ± 0.82a

15.89 ± 0.52b

< 0.0001

15.40 ± 2.02

21.48 ± 2.30

15.96 ± 2.30

0.13

n-3: n-6

0.08 ± 0.01a

0.06 ± 0.02a

0.18 ± 0.01b

< 0.0001

0.13 ± 0.01x

0.09 ± 0.02x

0.40 ± 0.02y

< 0.0001

  1. 1Values are least square means ± SEM. FA, fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid
  2. 2Values represent weight % of total fatty acids
  3. a, b, c; x, y, zMeans within a row lacking a common letter differ (P < 0.05)