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Table 6 Fatty acid composition of lung parenchymal tissue and porcine alveolar macrophages (PAM)1–2

From: Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages

Tissue Lung PAM
Diet CON LC n-6 LC n-3 P - value CON LC n-6 LC n-3 P - value
Fatty acid, g/100 g FA
14:0 1.62 ± 0.44 1.81 ± 0.38 2.04 ± 0.24 0.68 1.66 ± 0.19 1.53 ± 0.22 1.93 ± 0.22 0.45
16:0 31.38 ± 1.20 33.13 ± 1.04 33.45 ± 0.66 0.33 38.48 ± 3.31 33.62 ± 3.82 32.71 ± 3.82 0.47
16:1 0.66 ± 0.04 a 0.50 ± 0.04 b 0.50 ± 0.02 b 0.01 0.82 ± 0.13 0.46 ± 0.15 0.74 ± 0.15 0.22
18:0 20.56 ± 1.29 19.01 ± 1.12 20.23 ± 0.71 0.59 24.31 ± 1.65 25.44 ± 1.90 21.38 ± 1.90 0.32
18:1 22.94 ± 1.02 21.85 ± 0.88 22.82 ± 0.56 0.61 14.43 ± 1.18 13.02 ± 1.34 17.71 ± 1.34 0.06
18:2 10.06 ± 0.54 a 8.21 ± 0.47 b 10.83 ± 0.30 a 0.0002 5.76 ± 0.73xy 5.22 ± 0.84x 8.11 ± 0.84y 0.06
18:3 (n-6) 0.12 ± 0.03 a 0.02 ± 0.03 b 0.00 ± 0.02 b 0.01 1.25 ± 0.19 1.48 ± 0.22 1.23 ± 0.22 0.67
18:3 (n-3) 0.22 ± 0.07 0.17 ± 0.06 0.16 ± 0.04 0.76 0.03 ± 0.04x 0.00 ± 0.04x 0.17 ± 0.04y 0.02
20:0 0.40 ± 0.09 0.45 ± 0.07 0.45 ± 0.05 0.86 0.58 ± 0.08 0.38 ± 0.09 0.55 ± 0.09 0.27
20:1 0.43 ± 0.05 a 0.28 ± 0.04 b 0.30 ± 0.03 b 0.03 0.47 ± .09 0.23 ± 0.10 0.47 ± 0.10 0.16
20:2 0.7 ± 0.053a 0.56 ± 0.04 b 0.50 ± 0.03 b 0.001 0.73 ± 0.12 0.58 ± 0.14 0.34 ± 0.14 0.15
20:4 (n-6) 8.26 ± 0.60 a 11.55 ± 0.52 b 4.56 ± 0.33 c < 0.0001 7.66 ± 1.40x 14.22 ± 1.62y 6.27 ± 1.62x 0.01
20:3 (n-3) 0.62 ± 0.08 0.43 ± 0.07 0.60 ± 0.04 0.10 0.70 ± 0.11 0.67 ± 0.12 0.57 ± 0.12 0.74
20:5 (n-3) 0.00 ± 0.15a 0.00 ± 0.13a 1.53 ± 0.08b <  0.0001 0.02 ± 0.28x 0.00 ± 0.33 x 3.44 ± 0.33y <  0.0001
22:0 0.68 ± 0.19 0.69 ± 0.16 0.85 ± 0.10 0.60 1.90 ± 0.18 1.81 ± 0.21 1.88 ± 0.20 0.95
22:1 0.60 ± 0.22 0.73 ± 0.19 0.56 ± 0.12 0.74 0.02 ± 0.05x 0.00 ± 0.06x 0.23 ± 0.06y 0.03
22:6 (n-3) 0.63 ± 0.11 0.63 ± 0.10 0.62 ± 0.06 0.99 1.19 ± 0.26x 1.34 ± 0.30x 2.27 ± 0.30y 0.04
Total 100 100 100   100 100 100  
MUFA 24.63 ± 1.11 23.36 ± 0.96 24.18 ± 0.61 0.67 15.73 ± 1.32 13.72 ± 1.50 19.15 ± 1.50 0.06
PUFA 20.65 ± 1.17 21.57 ± 1.02 18.80 ± 0.64 0.07 17.34 ± 2.23 23.50 ± 2.76 22.41 ± 2.76 0.21
n-3 FA 1.47 ± 0.31a 1.23 ± 0.27a 2.91 ± 0.17b < 0.0001 1.94 ± 0.63x 2.01 ± 0.57x 6.45 ± 0.57y < 0.0001
n-6 FA 19.18 ± 0.94a 20.34 ± 0.82a 15.89 ± 0.52b < 0.0001 15.40 ± 2.02 21.48 ± 2.30 15.96 ± 2.30 0.13
n-3: n-6 0.08 ± 0.01a 0.06 ± 0.02a 0.18 ± 0.01b < 0.0001 0.13 ± 0.01x 0.09 ± 0.02x 0.40 ± 0.02y < 0.0001
  1. 1Values are least square means ± SEM. FA, fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid
  2. 2Values represent weight % of total fatty acids
  3. a, b, c; x, y, zMeans within a row lacking a common letter differ (P < 0.05)