Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages

Walter, Kathleen R.; Lin, Xi; Jacobi, Sheila K.; Käser, Tobias; Esposito, Debora; Odle, Jack

doi:10.1186/s40104-019-0321-1

Journal of Animal Science and Biotechnology

Table 5 Serum metabolite and enzyme concentrations and whole-blood cell from milk replacer-fed pigs^1,2

From: Dietary arachidonate in milk replacer triggers dual benefits of PGE₂ signaling in LPS-challenged piglet alveolar macrophages

Diet	CON	LC n-6	LC n-3	SEM	P-value
Blood chemistry panel
Total protein, g/dL	5.25	4.7	5	0.3	0.45
Albumin, g/dL	2.75^a	2.63^a	3.03^b	0.05	0.002
Globulin, g/dL	2.5	2.08	1.98	0.28	0.40
Albumin/Globulin ratio	1.2	1.3	1.56	0.16	0.29
Aspartate transaminase, U/L	24.25	20.25	32	6.68	0.48
Alanine transaminase, U/L	27.75	21.75	23	3.85	0.53
Alkaline phosphatase, U/L	636	750	702	69.32	0.53
Gama-glutamyl transpeptidase, U/L	37.75	31.75	24.25	8.47	0.55
Total bilirubin, mg/dL	0.1	0.1	0.13	0.01	0.41
Urea nitrogen, mg/dL	3^a	2.25^b	2^bc	0.14	0.002
Creatinine, mg/dL	0.73	0.73	0.7	0.06	0.95
Blood urea nitrogen/Creatinine ratio	4.25	3	3	0.36	0.06
Phosphorus, mg/dL	11.7	11.45	11.5	0.31	0.83
Glucose, mg/dL	137	156	137	7.37	0.18
Calcium, mg/dL	12.55	12.38	12.33	0.16	0.59
Magnesium, mEq/L	2.2	2.2	2.13	0.12	0.88
Sodium, mEq/L	139	136	137	1.08	0.29
Potassium, mEq/L	7.125	7.5	7.33	0.45	0.84
Sodium/Potassium ratio	19.75	18	19	1.32	0.66
Chloride, mEq/L	101	101	101	0.91	0.93
Cholesterol, mg/dL	107^a	105^a	87.25^b	5.21	0.05
Triglycerides, mg/dL	148	114	88.75	20.78	0.18
Amylase, U/L	1781	1648.25	5030	1889	0.40
Creatine phosphokinase, U/L	515	366	333	96.32	0.40
Complete blood count
White blood cells, 10³/μL	11.75	9.4	8.43	1.43	0.29
Red blood cells, 10⁶/μL	5.55	5.6	6.15	0.18	0.08
Hemoglobin, g/dL	10.1	9.95	10.8	0.34	0.22
Hematocrit, %	36.5	33.75	36.25	1.23	0.27
Mean corpuscular volume, fL	66.25^a	60.25^b	59^bc	1.63	0.03
Mean corpuscular hemoglobin, pg	18.25	17.78	17.58	0.45	0.57
Mean corpuscular hemoglobin concentration, g/dL	27.65	29.63	29.75	0.74	0.14
Platelet count, 10³/μL	578	486.25	360.25	124.27	0.49
Neutrophils, %	34.75	37.5	39.35	6.02	0.87
Bands, μL	0	0	0	0	–
Lymphocytes, %	58.5	52.5	52.5	5.48	0.68
Monocytes, %	5.50	5.75	5.00	0.91	0.84
Eosinophils, %	1.25	4.25	3.25	1.65	0.46
Basophils, %	0	0	0	0	–

¹Diets contained 0.5% ARA (CON), 2.2% ARA (LC n-6) or 3.0% EPA (LC n-3) of total fatty acids
²Values are least-square means and SEM, n = 4
^{a, b, c}Means within a row lacking a common letter differ (P < 0.05)

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ISSN: 2049-1891

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