Table 4 Key differentially methylated genes possibly related to hypoxic adaption in Tibetan pigs
From: Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under high-altitude hypoxia
Gene | Description | TH vs. YH | TL vs. YL | TH vs. TL | YH vs. YL | Functional annotation |
|---|---|---|---|---|---|---|
AKT3 | AKT serine/threonine kinase 3 | + | – | – | – | HIF-1 signaling pathway, VEGF signaling pathway, pathways in cancer |
ANGPT2 | Angiopoietin 2 | + | + | + | – | Angiogenesis, HIF-1 signaling pathway |
CAT | Catalase | + | – | – | – | Oxygen species, apoptosis process, mitochondrion |
CD38 | Cluster of differentiation 38 | + | + | + | + | Calcium signaling pathway |
EIF4E2 | Eukaryotic translation initiation factor 4E family member 2 | + | – | – | – | HIF-1 signaling pathway, mTOR signaling pathway, insulin signaling pathway |
EPAS1 | Endothelial PAS domain protein 1 | + | + | – | – | Angiogenesis, mitochondrion, response to hypoxia |
ERG | ETS transcription factor-related gene | + | + | + | + | Cell differentiation |
FADD | Fas associated via death domain | + | – | – | – | Apoptosis, pathways in cancer |
FGFR2 | Fibroblast growth factor receptor 2 | + | + | – | + | Angiogenesis, Pathways in cancer |
FOXO1 | Forkhead box O1 | + | + | – | – | Apoptotic process, response to hyperoxia |
GRB2 | Growth factor receptor bound protein 2 | + | – | – | – | MAPK signaling pathway, insulin signaling pathway, pathways in cancer |
HK2 | Hexokinase 2 | + | + | – | – | HIF-1 signaling pathway |
ICA | Porcine inhibitor of carbonic anhydrase | + | + | + | – | HIF-1 signaling pathway |
IGF1R | Insulin-like growth factor 1 receptor | + | + | – | – | Apoptosis process, HIF-1 signaling pathway |
IL6R | Interleukin 6 receptor | + | – | – | – | HIF-1 signaling pathway, PI3K-Akt signaling pathway |
KIT | KIT proto-oncogene receptor tyrosine kinase | + | + | – | – | Inflammatory response, ATP binding, pathways in cancer |
MAP2K1 | Mitogen-activated protein kinase 1 | + | – | + | – | HIF-1 signaling pathway, VEGF signaling pathway |
SMAD2 | SMAD family member 2 | + | – | – | – | TGF-beta signaling pathway |
STAT5B | Signal transducer and activator of transcription 5B | + | – | – | – | Apoptosis process, erythrocyte differentiation, pathways in cancer |