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Table 4 Key differentially methylated genes possibly related to hypoxic adaption in Tibetan pigs

From: Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under high-altitude hypoxia

Gene Description TH vs. YH TL vs. YL TH vs. TL YH vs. YL Functional annotation
AKT3 AKT serine/threonine kinase 3 + HIF-1 signaling pathway, VEGF signaling pathway, pathways in cancer
ANGPT2 Angiopoietin 2 + + + Angiogenesis, HIF-1 signaling pathway
CAT Catalase + Oxygen species, apoptosis process, mitochondrion
CD38 Cluster of differentiation 38 + + + + Calcium signaling pathway
EIF4E2 Eukaryotic translation initiation factor 4E family member 2 + HIF-1 signaling pathway, mTOR signaling pathway, insulin signaling pathway
EPAS1 Endothelial PAS domain protein 1 + + Angiogenesis, mitochondrion, response to hypoxia
ERG ETS transcription factor-related gene + + + + Cell differentiation
FADD Fas associated via death domain + Apoptosis, pathways in cancer
FGFR2 Fibroblast growth factor receptor 2 + + + Angiogenesis, Pathways in cancer
FOXO1 Forkhead box O1 + + Apoptotic process, response to hyperoxia
GRB2 Growth factor receptor bound protein 2 + MAPK signaling pathway, insulin signaling pathway, pathways in cancer
HK2 Hexokinase 2 + + HIF-1 signaling pathway
ICA Porcine inhibitor of carbonic anhydrase + + + HIF-1 signaling pathway
IGF1R Insulin-like growth factor 1 receptor + + Apoptosis process, HIF-1 signaling pathway
IL6R Interleukin 6 receptor + HIF-1 signaling pathway, PI3K-Akt signaling pathway
KIT KIT proto-oncogene receptor tyrosine kinase + + Inflammatory response, ATP binding, pathways in cancer
MAP2K1 Mitogen-activated protein kinase 1 + + HIF-1 signaling pathway, VEGF signaling pathway
SMAD2 SMAD family member 2 + TGF-beta signaling pathway
STAT5B Signal transducer and activator of transcription 5B + Apoptosis process, erythrocyte differentiation, pathways in cancer
  1. Note: “+” represents differentially methylated genes in some comparisons. “-” represents no differentially methylated genes. TH, Tibetan highland pig; YH, Yorkshire highland pig; TL, Tibetan lowland pig; YL, Yorkshire lowland pig