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Table 3 Metabolites with significant differences among feeding, 24 h of fasting and 48 h of fastinga

From: Integrative analysis of indirect calorimetry and metabolomics profiling reveals alterations in energy metabolism between fed and fasted pigs

No. Name m/z Formula Fold changeb Pathway analysis
FD/FS_24 FD/FS_48 FS_24/FS_48
1 12,13-DHOME 297.2420 C18H34O4 0.30 0.49 1.62 Linoleic acid metabolism
2 Linoleic acid 263.2366 C18H32O2 0.17 0.20 1.18 Linoleic acid metabolism
3 Stearidonic acid 277.2157 C18H28O2 0.11 0.11 1.02 alpha-Linolenic acid metabolism
4 Oleic acid 300.2893 C18H34O2 0.38 0.62 1.62 Fatty acid metabolism
5 Palmitoleic acid 255.2314 C16H30O2 0.21 0.25 1.17 Fatty acid metabolism
6 Pantothenic acid 220.1178 C9H17NO5 1.22 0.72 0.59 Pantothenate and CoA biosynthesis
7 Glycerophosphocholine 280.0917 C8H20NO6P 1.75 1.51 0.86 Ether lipid metabolism
8 LysoPC(O-18:0) 510.3912 C26H56NO6P 1.02 0.34 0.33 Ether lipid metabolism
9 Sphinganine 284.2942 C18H39NO2 0.37 0.46 1.24 Sphingolipid metabolism
10 5-Aminopentanoic acid 118.0864 C5H11NO2 1.30 0.84 0.65 Lysine degradation
11 Aminoadipic acid 144.0654 C6H11NO4 1.32 0.83 0.63 Lysine degradation
12 Betaine 140.0681 C5H11NO2 1.87 1.05 0.56 Glycine, serine and threonine metabolism
13 Ornithine 133.0972 C5H12N2O2 2.00 1.64 0.82 Arginine and proline metabolism
14 L-Glutamine 169.0582 C5H10N2O3 2.12 1.66 0.78 Arginine and proline metabolism
15 L-Tyrosine 199.1076 C9H11NO3 0.49 0.45 0.93 Nitrogen metabolism
  1. aFD: Feeding; FS_24: 24 h fasting; FS_48: 48 h fasting; 12,13-DHOME: 12,13-dihydroxyoctadecenoic acid; LysoPC(18:0): lysophosphatidylcholine 18:0
  2. bFold change was calculated by dividing the mean of normalized intensity of each plasma metabolite in the former by the mean of normalized intensity of each plasma in the latter. Fold change > 1 indicates that the metabolite was down-regulated, whereas fold change < 1 indicates the metabolite was up-regulated