Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

Table 3 Main functional categories of proteins affected by an interaction between genotype and developmental age effects in subcutaneous adipose tissue of pig fetuses

Functional annotation^a	P-value	Enrich.	Proteins
Cluster 1 (E score = 2.75)			AHSG, TF, GSN,
Response to organic substance	< 0.001	9.4	SERPINA1, PEPB1,
Response to hormone stimulus	0.003	12.3	IDH1
Cluster 2 (E score = 2.48)
Acute phase response	< 0.001	84.6	AHSG, SERPINA1, TF
Cluster 3 (E score = 1.90)
Negative regulation of signal transduction	0.013	15.3	AHSG, PEPB1, CALR
Cluster 4 (E score = 1.65)			APOA1, CALR, TF
Chemical homeostasis	0.007	8.8	HSP90B1
Cluster 5 (E score = 1.47)			AHSG, PEPB1, CALR,
Macromolecular complex assembly	0.015	6.8	GSN
Cluster 6 (E score = 1.38)
Maintenance of location	0.01	52.8	ALB, PEPB1, CALR
Regulation of apoptosis	0.10	4.2

^aThe E score of the cluster was measured by minus log transformation of the geometric mean of the modified Fisher Exact EASE Scores of all annotation terms that belong to this cluster, and it was intended to order the relative importance of the different clusters. The fold enrichments (enrich.) of specific individual annotation terms were also indicated for the most biologically-informative terms within each cluster

ISSN: 2049-1891