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Table 2 Main biological processes and functional categories of proteins in subcutaneous adipose tissue of pig fetuses as affected by genotype

From: Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

Functional annotationa P-value Enrich. Identified proteinsb
Cluster 1 (E score = 2.44)    MeiS > LW: SPTAN1, GSN LW ≥ MeiS: ARHGDIA,MYL6, MYL12A, VIM, APOA1, CAPZB F1_LW ≥ F1_MeiS: ARHGDIA, APOA1
 Negative regulation of cellular component organization < 0.001 21.6
 Actin capping  Regulation of actin filament-based process < 0.001 0.008 126 20.0
Cluster 2 (E score = 2.17)    MeiS > LW: FABP3, FABP4, TF, CLIC1 LW ≥ MeiS: APOA1 F1_MeiS > F1_LW: FABP3, TF F1_LW ≥ F1_MeiS: APOA1
 Lipid binding  PPAR signaling pathway 0.02 0.01 133.0 17.0
Cluster 3 (E score = 1.96)    MeiS > LW: HSPA1B, ALB, NME1 LW ≥ MeiS: ARHGDIA, PDIA3, CSTB F1_MeiS > F1_LW: ALDOC, FABP3, TF, NME1 F1_LW ≥ F1_MeiS: ARHGDIA
 Regulation of apoptosis  Regulation of programmed cell death 0.007 0.007 4.5 4.5
Cluster 4 (E score = 1.74)    LW ≥ MeiS: PRDX6, PDIA6, PDIA3
 Cell redox homeostasis 0.004 29.3
Cluster 5 (E score = 1.40)    MeiS > LW: TF, ALB LW ≥ MeiS: APOA1 F1_MeiS > F1_LW: TF F1_LW ≥ F1_MeiS: APOA1
 Plasma 0.004 25.8
Cluster 6 (E score = 1.23)    MeiS > LW: ALDOC, NME1, FABP3, FABP4, CLIC1, TF, ALB, HSPA1B, GSN F1_MeiS > F1_LW: ALDOC, FABP3, TF, NME1
 Response to nutrient levels  Response to extracellular stimulus 0.04 0.04 9.4 8.4
  1. aThe E score of the cluster was measured by minus log transformation of the geometric mean of the modified Fisher Exact EASE Scores of all annotation terms that belong to this cluster, and it was intended to order the relative importance of the different clusters. The fold enrichments (enrich.) of specific individual annotation terms were also indicated for the most biologically-informative terms within each cluster
  2. bLists of regulated proteins participating to each cluster were indicated. MeiS > LW: proteins having a higher abundance in pure Meishan than in pure Large White genotypes. LW > MeiS: proteins having a higher abundance in pure Large White than in pure Meishan genotypes. F1_MeiS > F1_LW: proteins having a higher abundance in crossbred (F1) fetuses gestated by MeiS sows when compared with those gestated by Large White sows. F1_LW > F1_MeiS: proteins having a higher abundance in crossbred (F1) fetuses gestated by Large White sows when compared with those gestated by Meishan sows