Functional annotationa | P-value | Enrich. | Identified proteinsb |
---|---|---|---|
Cluster 1 (E score = 3.70) | d 110 ≥ d 90: | ||
Pyruvate metabolism | < 0.001 | 20.5 | LDHB, MDH1, PDHB, AKR1B1, |
Oxidation reduction | < 0.001 | 6.2 | ACADS, PTGR2, ALDH9A1, PRDX1, PRDX6 |
Cluster 2 (E score = 2.55) | d 110 ≥ d 90: | ||
Glycolysis | < 0.001 | 13.7 | LDHB, MDH1, PDHB, ALDOC, |
Hexose process | < 0.001 | 9.0 | GALM, GALK1, ALDH9A1 |
Generation of precursor metabolites and energy | 0.02 | 4.6 | d 90 ≥ d 110: ATP5B |
Cluster 3 (E score = 2.46) | d 110 ≥ d 90: | ||
Actin binding | 0.003 | 7.8 | GSN d 90 ≥ d 110: CFL1, VCL, FSCN1, TPM3 |
Cluster 4 (E score = 2.11) | d 110 ≥ d 90: FABP3, FABP4, APOA1 d 90 ≥ d 110: VCL, APOA1 | ||
Lipid binding | < 0.001 | 85.4 | |
Cluster 5 (E score = 2.01) | d 110 ≥ d 90: HSPD1, HSPA1B d 90 ≥ d 110: HSPA8, CLIC1 | ||
Response to protein stimulus | 0.005 | 10.8 | |
Molecular chaperone | < 0.001 | 88.8 | |
Cluster 6 (E score = 1.67) | d 110 ≥ d 90: GSN, MYL12A, MYL12B, CRKL d 90 ≥ d 110: CFL1, ACTB, VCL | ||
Regulation of actin cytoskeleton | 0.001 | 5.3 | |
Cluster 7 (E score = 1.59) | d 110 ≥ d 90: HSPD1, HSPA1B, PHB, PRDX1, ANXA4 d 90 ≥ d 110: CFL1, LGALS1, ARHGDIA | ||
Regulation of apoptosis | 0.020 | 2.9 | |
Cluster 8 (E score = 1.47) | d 110 ≥ d 90: GSN | ||
Cytoskeleton organization | 0.015 | 4.0 | |
Actin filament organization | 0.02 | 12.0 | d 90 ≥ d 110: TUBA1B, TUBB, CFL1, FSCN1, TPM3, DES, STMN1 |
Cluster 9 (E score = 1.46) | d 110 ≥ d 90: CRKL, APOA1 d 90 ≥ d 110: ARHGDIA, CFL1, APOA1 | ||
Ras protein signal transduction | 0.005 | 10.9 | |
Rho protein signal transduction | 0.007 | 22.8 | |
Cluster 10 (E score = 1.45) | d 110 ≥ d 90: ALDOC, ACADS, FABP3, FABP4 d 90 ≥ d 110: AHSG, CFL1, SERPINA1 | ||
Response to endogenous stimulus | 0.002 | 5.0 | |
Response to hormone stimulus | 0.03 | 3.9 | |
Cluster 11 (E score = 1.41) | d 110 ≥ d 90: PRDX1, PRDX6 d 90 ≥ d 110: PDIA6 | ||
Cell redox homeostasis | 0.020 | 13.7 | |
Cluster 12 (E score = 1.18) | d 110 ≥ d 90: TPM3, APOA1, VIM d 90 ≥ d 110: ATP5B, CFL1, ACTB, VCL, ARHGDIA, APOA1, VIM | ||
Cell motion | 0.001 | 4.8 | |
Cluster 13 (E score = 1.10) | d 110 ≥ d 90: CLEC3B, APOA1 d 90 ≥ d 110: AFP, AHSG, SERPINA1, APOA1 | ||
Plasma | < 0.001 | 20.6 |