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Table 1 Main biological processes and functional categories of proteins in subcutaneous adipose tissue of pig fetuses as affected by age of development

From: Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

Functional annotationa

P-value

Enrich.

Identified proteinsb

Cluster 1 (E score = 3.70)

  

d 110 ≥ d 90:

 Pyruvate metabolism

< 0.001

20.5

LDHB, MDH1, PDHB, AKR1B1,

 Oxidation reduction

< 0.001

6.2

ACADS, PTGR2, ALDH9A1, PRDX1, PRDX6

Cluster 2 (E score = 2.55)

  

d 110 ≥ d 90:

 Glycolysis

< 0.001

13.7

LDHB, MDH1, PDHB, ALDOC,

 Hexose process

< 0.001

9.0

GALM, GALK1, ALDH9A1

 Generation of precursor metabolites and energy

0.02

4.6

d 90 ≥ d 110:

ATP5B

Cluster 3 (E score = 2.46)

  

d 110 ≥ d 90:

 Actin binding

0.003

7.8

GSN

d 90 ≥ d 110:

CFL1, VCL, FSCN1, TPM3

Cluster 4 (E score = 2.11)

  

d 110 ≥ d 90:

FABP3, FABP4, APOA1

d 90 ≥ d 110:

VCL, APOA1

 Lipid binding

< 0.001

85.4

Cluster 5 (E score = 2.01)

  

d 110 ≥ d 90:

HSPD1, HSPA1B

d 90 ≥ d 110:

HSPA8, CLIC1

 Response to protein stimulus

0.005

10.8

 Molecular chaperone

< 0.001

88.8

Cluster 6 (E score = 1.67)

  

d 110 ≥ d 90:

GSN, MYL12A, MYL12B, CRKL

d 90 ≥ d 110:

CFL1, ACTB, VCL

 Regulation of actin cytoskeleton

0.001

5.3

Cluster 7 (E score = 1.59)

  

d 110 ≥ d 90:

HSPD1, HSPA1B, PHB, PRDX1, ANXA4

d 90 ≥ d 110:

CFL1, LGALS1, ARHGDIA

 Regulation of apoptosis

0.020

2.9

Cluster 8 (E score = 1.47)

  

d 110 ≥ d 90:

GSN

 Cytoskeleton organization

0.015

4.0

 Actin filament organization

0.02

12.0

d 90 ≥ d 110:

TUBA1B, TUBB, CFL1, FSCN1, TPM3, DES, STMN1

Cluster 9 (E score = 1.46)

  

d 110 ≥ d 90:

CRKL, APOA1

d 90 ≥ d 110:

ARHGDIA, CFL1, APOA1

 Ras protein signal transduction

0.005

10.9

 Rho protein signal transduction

0.007

22.8

Cluster 10 (E score = 1.45)

  

d 110 ≥ d 90:

ALDOC, ACADS, FABP3, FABP4

d 90 ≥ d 110:

AHSG, CFL1, SERPINA1

 Response to endogenous stimulus

0.002

5.0

 Response to hormone stimulus

0.03

3.9

Cluster 11 (E score = 1.41)

  

d 110 ≥ d 90:

PRDX1, PRDX6

d 90 ≥ d 110:

PDIA6

 Cell redox homeostasis

0.020

13.7

Cluster 12 (E score = 1.18)

  

d 110 ≥ d 90:

TPM3, APOA1, VIM

d 90 ≥ d 110:

ATP5B, CFL1, ACTB, VCL, ARHGDIA, APOA1, VIM

 Cell motion

0.001

4.8

Cluster 13 (E score = 1.10)

  

d 110 ≥ d 90:

CLEC3B, APOA1

d 90 ≥ d 110:

AFP, AHSG, SERPINA1, APOA1

 Plasma

< 0.001

20.6

  1. aThe E score of the cluster was measured by minus log transformation of the geometric mean of the modified Fisher Exact EASE Scores of all annotation terms that belong to this cluster, and it was intended to order the relative importance of the different clusters. The fold enrichments (enrich.) of specific individual annotation terms were also indicated for the most biologically-informative terms within each cluster
  2. bLists of regulated proteins participating to each cluster were indicated. d 110 > d 90: proteins having a higher abundance in subcutaneous adipose tissue of fetuses at 110 d of gestation than at 90 d of gestation. d 90 > d 110: proteins having a higher abundance in subcutaneous adipose tissue of fetuses at 90 d of gestation than at 110 d of gestation. APOA1 and VIM were represented by spots with an opposite regulation by age of gestation