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Fig. 4 | Journal of Animal Science and Biotechnology

Fig. 4

From: Primordial germ cell-mediated transgenesis and genome editing in birds

Fig. 4

Strategies for the production of genome-edited birds. Avian PGCs can be isolated from embryonic blood (HH stages 14–16) and embryonic gonads (HH stage 26–28) by cell-surface antibody-mediated methods, density gradient centrifugation, and size-dependent isolation methods. Genome-edited birds can be produced by transplanting directly isolated or in vitro cultured PGCs into the blood vessels of recipient embryos after the introduction of genome editing tools. Avian genome editing systems can be applied to produce various avian models, such as avian disease resistance models, bioreactor models, and human disease models

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