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Fig. 6 | Journal of Animal Science and Biotechnology

Fig. 6

From: Development of genome engineering technologies in cattle: from random to specific

Fig. 6

Illustration of knock-out/-in cattle. SCNT combined with homologous recombination (HR) and genome editing is a useful approach, though it is limited by abnormal reprograming and low success rates. Simple micro-injection of Cas9 and sgRNA for the target region will be useful for the production of genome edited cattle with high efficiency and genomic stability. NHEJ: Non-homologous end joining; HDR: Homology directed repair

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