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Table 3 Effects of subcutaneous injections of TNFα receptor loop peptide (TRLP)a on glucose tolerance test (GTT) responses in energy restricted cowsb (n = 5)

From: Effects of TNF receptor blockade on in vitro cell survival and response to negative energy balance in dairy cattle

 

Infusion Treatment

 

P- value

Control

TRLP

SEM

Glucose response, mg/dL × min

 AUCc

4024

4223

462.8

0.77

 AUCd

5226

4932

738.5

0.79

Insulin response, ng/mL × min

 AUCc

77.3

73.9

32.6

0.94

 AUCd

151.8

140.9

44.3

0.86

NEFA response, μEq/L × min

 AUCc

−4092

−2103

1081

0.25

 AUCd

−14,674

−11,427

2034

0.31

  1. aCows were administered daily subcutaneous injections of TRLP at 1.75 mg/kg BW/d distributed in 6 doses daily (every 4 h) for 7 d
  2. bCows were fed a diet restricted to provide 30% of estimated energy requirements for maintenance
  3. cIncremental area under the curve at 60 min post-dextrose bolus
  4. dIncremental area under the curve at 120 min post-dextrose bolus